Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15383..15641 Replicon chromosome
Accession NZ_CP007491
Organism Escherichia coli strain ACN002

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag ACN002_RS00080 Protein ID WP_000809168.1
Coordinates 15383..15535 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15584..15641 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACN002_RS00060 10624..11337 - 714 WP_001102383.1 acidic protein MsyB -
ACN002_RS00065 11363..11767 - 405 WP_000843559.1 DUF2541 family protein -
ACN002_RS00070 12144..14060 + 1917 WP_000516131.1 molecular chaperone DnaK -
ACN002_RS00075 14149..15279 + 1131 WP_001118464.1 molecular chaperone DnaJ -
ACN002_RS00080 15383..15535 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15584..15641 + 58 - - Antitoxin
ACN002_RS00085 16121..17287 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
ACN002_RS00090 17353..18252 + 900 WP_001300855.1 transcriptional activator NhaR -
ACN002_RS26460 18291..19249 - 959 Protein_17 fimbrial family protein -
ACN002_RS00105 19262..20593 - 1332 Protein_18 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T46506 WP_000809168.1 NZ_CP007491:c15535-15383 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T46506 NZ_CP007491:c15535-15383 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT46506 NZ_CP007491:15584-15641 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References