Detailed information of TA system TA046463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2812403..2813055
• Replicon: chromosome
• Accession: NZ_CP007448
• Organism: Yersinia enterocolitica LC20

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LC20_RS13690
• Protein ID: WP_100273940.1
• Coordinates: 2812403..2812585 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LC20_RS13695
• Protein ID: WP_025378632.1
• Coordinates: 2812642..2813055 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LC20_RS13650	2808281..2808721	+	441	WP_025378625.1	hypothetical protein	-
LC20_RS13655	2808923..2809177	-	255	WP_025378495.1	hypothetical protein	-
LC20_RS13660	2809180..2809794	-	615	WP_025378626.1	hypothetical protein	-
LC20_RS13665	2809791..2810300	-	510	WP_025378627.1	ParB/Srx family N-terminal domain-containing protein	-
LC20_RS13670	2810536..2810772	-	237	WP_025378628.1	hypothetical protein	-
LC20_RS13675	2810800..2811321	-	522	WP_100273939.1	DUF2514 family protein	-
LC20_RS13680	2811410..2811910	-	501	WP_100274024.1	lysozyme	-
LC20_RS13685	2811935..2812246	-	312	WP_025378631.1	hypothetical protein	-
LC20_RS13690	2812403..2812585	+	183	WP_100273940.1	type II toxin-antitoxin system HicA family toxin	Toxin
LC20_RS13695	2812642..2813055	+	414	WP_025378632.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LC20_RS13700	2813252..2813929	-	678	WP_025378633.1	antitermination protein	-
LC20_RS13705	2813929..2814216	-	288	WP_025378634.1	DUF1364 domain-containing protein	-
LC20_RS13710	2814225..2814818	-	594	WP_025378635.1	DUF1367 family protein	-
LC20_RS13715	2814895..2815077	-	183	WP_025378636.1	hypothetical protein	-
LC20_RS13720	2815398..2817593	-	2196	WP_100273941.1	DNA cytosine methyltransferase	-
LC20_RS13725	2817590..2817799	-	210	WP_025378637.1	hypothetical protein	-
LC20_RS13730	2817792..2818001	-	210	WP_025378638.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2783238..2844711	61473

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6896.11 Da
• Isoelectric Point: 10.7089

>T46463 WP_100273940.1 NZ_CP007448:2812403-2812585 [Yersinia enterocolitica LC20]
MKSSELMRLLEEYGWEMVRIKGSHHTFKHPDSANLVTVPHPTKEIKAGTLRQILRKAGIK

Nucleotide

• Length: 183 bp

>T46463 NZ_CP007448:2812403-2812585 [Yersinia enterocolitica LC20]
TTGAAGAGTTCGGAACTGATGAGGCTGTTAGAAGAATATGGTTGGGAAATGGTAAGAATTAAAGGCAGTCACCATACGTT
TAAACATCCAGATTCAGCTAACTTAGTAACAGTACCCCATCCCACTAAAGAGATTAAAGCCGGAACACTGAGGCAAATCT
TGAGAAAGGCAGGGATCAAGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15269.01 Da
• Isoelectric Point: 4.6403

>AT46463 WP_025378632.1 NZ_CP007448:2812642-2813055 [Yersinia enterocolitica LC20]
MHYPAFIEIDKDGTASGWFPDVDGCIFAGDTVDDAFIDAQSAIDAHFEALVEHGMEIPAPKTMQEHIVNDATEYVNGQWA
LINVNMDKFDGRAERINITLPHRLLHQIDSVVRSKPEYSSRSGFIAAATRNELHRAS

Nucleotide

• Length: 414 bp

>AT46463 NZ_CP007448:2812642-2813055 [Yersinia enterocolitica LC20]
ATGCATTACCCAGCATTTATTGAGATAGACAAAGACGGCACAGCCAGCGGATGGTTTCCCGATGTAGATGGTTGCATTTT
TGCCGGTGATACGGTTGATGATGCTTTCATCGACGCACAAAGCGCAATTGATGCTCACTTTGAAGCATTAGTTGAGCACG
GCATGGAAATACCTGCCCCAAAAACAATGCAGGAACACATTGTCAATGATGCCACCGAGTACGTTAATGGGCAGTGGGCG
TTGATCAATGTGAACATGGATAAATTTGACGGTCGCGCAGAGCGGATAAATATCACGTTGCCACATCGTTTATTACATCA
GATTGACAGTGTGGTAAGAAGCAAACCCGAGTACAGCAGCAGGAGCGGGTTTATCGCCGCTGCCACTCGTAACGAATTAC
ACAGAGCAAGTTAA