Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 92014..92759 Replicon chromosome
Accession NZ_CP007448
Organism Yersinia enterocolitica LC20

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag LC20_RS00405 Protein ID WP_025376492.1
Coordinates 92394..92759 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LC20_RS00400 Protein ID WP_025376491.1
Coordinates 92014..92358 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC20_RS00370 87510..87959 + 450 WP_025376485.1 hypothetical protein -
LC20_RS00375 88030..88161 + 132 Protein_69 DUF945 domain-containing protein -
LC20_RS00380 88234..89943 - 1710 WP_025376487.1 group II intron reverse transcriptase/maturase -
LC20_RS00385 90525..91214 + 690 Protein_71 DUF945 domain-containing protein -
LC20_RS00390 91285..91758 + 474 WP_025376489.1 DNA repair protein RadC -
LC20_RS00395 91769..91990 + 222 WP_025376490.1 DUF987 family protein -
LC20_RS00400 92014..92358 + 345 WP_025376491.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LC20_RS00405 92394..92759 + 366 WP_025376492.1 TA system toxin CbtA family protein Toxin
LC20_RS00410 92853..94101 + 1249 Protein_76 AAA family ATPase -
LC20_RS00415 94056..94259 + 204 WP_087769352.1 hypothetical protein -
LC20_RS00420 94259..94984 + 726 WP_025376494.1 TIGR02646 family protein -
LC20_RS00425 95133..95966 + 834 WP_025376495.1 DUF4942 domain-containing protein -
LC20_RS00430 96637..96990 + 354 WP_193588358.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(14-113)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13605.59 Da        Isoelectric Point: 9.6284

>T46447 WP_025376492.1 NZ_CP007448:92394-92759 [Yersinia enterocolitica LC20]
MNTSPATNQRVAKPCPSPVAVWQMLLTRLLAQHYGLALSDTPFNDESVIQEHINAGVTLADAVNFLVDKYELVRIDRKGF
SWQEQSPYLRAVDILRARKATGLLTRCKKHNGNQPDGRFTL

Download         Length: 366 bp

>T46447 NZ_CP007448:92394-92759 [Yersinia enterocolitica LC20]
ATGAACACCTCTCCTGCAACAAATCAGCGGGTGGCGAAGCCATGCCCGTCGCCTGTGGCCGTCTGGCAGATGTTACTTAC
CCGTTTACTTGCGCAGCACTATGGCCTGGCCCTGAGCGACACTCCATTCAATGATGAAAGTGTTATTCAGGAACATATCA
ACGCAGGCGTTACACTTGCCGATGCCGTGAACTTTCTGGTGGACAAATACGAACTCGTTCGTATCGATCGCAAAGGATTT
AGCTGGCAGGAACAATCACCCTATCTCCGGGCTGTCGATATTCTGCGGGCGCGGAAAGCAACGGGGTTGTTAACACGTTG
CAAAAAACACAATGGTAATCAGCCTGATGGCAGATTCACTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13106.14 Da        Isoelectric Point: 7.2626

>AT46447 WP_025376491.1 NZ_CP007448:92014-92358 [Yersinia enterocolitica LC20]
MKKDTANEVVDTLRWGLKCDITPHFEARLVQEGNRLHYLADRASIIGQFSKADLRHLNQAFPLLVKQMELMLTNGELNPQ
YQHCVTLYTKILTCEADTLGSCGYVYITIYLTQR

Download         Length: 345 bp

>AT46447 NZ_CP007448:92014-92358 [Yersinia enterocolitica LC20]
ATGAAAAAAGACACAGCCAATGAAGTAGTGGATACGCTGCGATGGGGACTGAAATGCGACATCACACCACATTTCGAGGC
CCGTCTGGTGCAGGAAGGCAACCGCCTGCATTACCTCGCCGATCGGGCCAGCATAATCGGTCAGTTCAGCAAAGCTGATT
TACGCCATCTCAACCAGGCTTTCCCCTTGTTGGTGAAGCAAATGGAACTCATGCTCACCAACGGAGAACTTAATCCCCAG
TACCAGCACTGCGTCACGCTATATACGAAGATATTAACCTGTGAAGCCGATACGCTCGGCTCCTGTGGCTACGTTTACAT
CACCATTTACCTCACTCAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References