Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6052106..6052778 Replicon chromosome
Accession NZ_CP007410
Organism Pseudomonas brassicacearum strain DF41

Toxin (Protein)


Gene name higB Uniprot ID W8Q2H0
Locus tag CD58_RS26080 Protein ID WP_025215813.1
Coordinates 6052413..6052778 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8QJ57
Locus tag CD58_RS26075 Protein ID WP_025215812.1
Coordinates 6052106..6052420 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD58_RS26065 6049246..6051573 + 2328 WP_025215810.1 hypothetical protein -
CD58_RS26070 6051609..6052070 + 462 WP_025215811.1 Lrp/AsnC family transcriptional regulator -
CD58_RS26075 6052106..6052420 - 315 WP_025215812.1 XRE family transcriptional regulator Antitoxin
CD58_RS26080 6052413..6052778 - 366 WP_025215813.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CD58_RS26085 6053141..6054823 + 1683 WP_025215814.1 NAD(P)/FAD-dependent oxidoreductase -
CD58_RS26090 6054836..6055630 + 795 WP_025215815.1 carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(5-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14232.94 Da        Isoelectric Point: 5.2385

>T46418 WP_025215813.1 NZ_CP007410:c6052778-6052413 [Pseudomonas brassicacearum]
MKWDVEYTDEFERWWNRLCESEQDSVQASVMLLGDTGPYLGFPHTSDIKGSRHGNLRELRVQYAGRPYRVLYAFDPRRCA
ILLIGGDKTGQGRWYQEYVPLAERLYDEHLEVLKREGFDNG

Download         Length: 366 bp

>T46418 NZ_CP007410:c6052778-6052413 [Pseudomonas brassicacearum]
ATGAAATGGGACGTTGAGTACACAGACGAATTTGAGAGGTGGTGGAACCGTCTCTGTGAATCTGAGCAAGATTCGGTACA
GGCCTCGGTAATGCTGCTCGGCGACACCGGGCCGTATCTGGGCTTTCCTCACACCAGTGATATCAAAGGTTCGCGTCATG
GCAACCTTCGTGAGTTACGAGTGCAATACGCAGGTAGGCCTTATCGTGTGCTCTATGCGTTTGATCCCCGCCGCTGCGCC
ATCCTGCTGATCGGGGGAGACAAAACCGGCCAGGGCCGTTGGTATCAGGAATATGTGCCTTTGGCCGAACGCCTCTATGA
CGAGCATTTGGAAGTATTGAAGAGAGAGGGCTTTGACAATGGCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11872.62 Da        Isoelectric Point: 9.6213

>AT46418 WP_025215812.1 NZ_CP007410:c6052420-6052106 [Pseudomonas brassicacearum]
MAKKFSDLMARRSPDSQARAQALYQTLRAEMPLHELRQAQELSQEALAKALHINQAAVSKMERRTDMYISTLRNYIRAMG
GELEIIATFPEGQVRIENFSHPTP

Download         Length: 315 bp

>AT46418 NZ_CP007410:c6052420-6052106 [Pseudomonas brassicacearum]
ATGGCTAAGAAATTTTCCGACTTGATGGCGCGTCGGTCGCCTGACTCCCAGGCTCGTGCACAGGCTCTGTATCAGACGTT
GCGTGCAGAAATGCCGTTGCACGAGTTGCGCCAGGCGCAGGAGTTGAGCCAGGAGGCCTTGGCCAAGGCACTGCATATCA
ACCAGGCGGCAGTCTCGAAAATGGAGCGCCGGACGGATATGTACATCAGCACGTTGCGAAATTACATCCGGGCCATGGGA
GGGGAATTGGAGATTATCGCGACCTTTCCAGAGGGGCAGGTCAGGATCGAAAATTTCTCCCATCCAACACCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Q2H0

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5FD61

References