Detailed information of TA system TA046101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 866672..867075
• Replicon: chromosome
• Accession: NZ_CP007139
• Organism: Fimbriimonas ginsengisoli Gsoil 348

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: OP10G_RS25605
• Protein ID: WP_173425311.1
• Coordinates: 866672..866857 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: OP10G_RS25610
• Protein ID: WP_084178800.1
• Coordinates: 866854..867075 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OP10G_RS04010	862808..863293	-	486	WP_025227166.1	DUF4375 domain-containing protein	-
OP10G_RS04015	863414..864745	-	1332	WP_025227165.1	alpha-L-fucosidase	-
OP10G_RS04020	864812..865819	+	1008	WP_025227164.1	DUF2332 domain-containing protein	-
OP10G_RS04035	866378..866581	-	204	WP_025227163.1	hypothetical protein	-
OP10G_RS25605	866672..866857	+	186	WP_173425311.1	type II toxin-antitoxin system HicA family toxin	Toxin
OP10G_RS25610	866854..867075	+	222	WP_084178800.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
OP10G_RS04040	867125..869749	-	2625	WP_025227162.1	exo-alpha-sialidase	-
OP10G_RS23945	869800..870780	-	981	WP_144240987.1	menaquinone biosynthesis protein	-
OP10G_RS04050	870777..871502	-	726	WP_025227160.1	class I SAM-dependent methyltransferase	-
OP10G_RS04055	871701..871943	-	243	WP_084179735.1	DUF433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-67)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6995.89 Da
• Isoelectric Point: 10.9595

>T46101 WP_173425311.1 NZ_CP007139:866672-866857 [Fimbriimonas ginsengisoli Gsoil 348]
VTVRDAIRKIEQDGWKQVRQTGSHRHYRHPTKPGTVTIPGHFSDDLHPKTENSILKQAGLR

Nucleotide

• Length: 186 bp

>T46101 NZ_CP007139:866672-866857 [Fimbriimonas ginsengisoli Gsoil 348]
GTGACCGTTCGGGACGCCATTCGAAAGATTGAACAGGACGGATGGAAGCAGGTTCGCCAAACGGGAAGCCACCGACATTA
CCGGCATCCAACCAAGCCAGGAACGGTGACCATACCCGGACACTTTTCTGACGACCTTCACCCTAAAACCGAGAACAGCA
TCCTAAAACAGGCAGGCCTACGATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 7989.98 Da
• Isoelectric Point: 4.2498

>AT46101 WP_084178800.1 NZ_CP007139:866854-867075 [Fimbriimonas ginsengisoli Gsoil 348]
MSSLAYSVVYETQPGSNWSAYVPDLPGCVSTGKTLDEIQRNIREAVEGHIQVMREFGDEIPHPSTLVGVVEVV

Nucleotide

• Length: 222 bp

>AT46101 NZ_CP007139:866854-867075 [Fimbriimonas ginsengisoli Gsoil 348]
ATGAGTTCATTAGCTTATTCCGTCGTCTATGAGACCCAACCAGGTTCCAATTGGAGTGCTTACGTCCCCGACCTTCCCGG
GTGCGTTTCAACCGGAAAAACACTTGACGAGATCCAACGAAATATCCGTGAAGCGGTCGAAGGGCACATTCAAGTGATGA
GGGAATTCGGCGATGAAATCCCTCATCCATCCACGCTTGTTGGCGTTGTAGAGGTCGTCTGA