Detailed information of TA system TA045821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 562874..564408
• Replicon: chromosome
• Accession: NZ_CP006954
• Organism: Bibersteinia trehalosi USDA-ARS-USMARC-188

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A4V7I8D4
• Locus tag: F542_RS02745
• Protein ID: WP_015433059.1
• Coordinates: 563122..564408 (+)
• Length: 429 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: F542_RS02740
• Protein ID: WP_015433060.1
• Coordinates: 562874..563128 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F542_RS02710	557978..558619	+	642	WP_025266847.1	orotate phosphoribosyltransferase	-
F542_RS02715	558670..559251	-	582	WP_015433066.1	rhomboid family intramembrane serine protease	-
F542_RS02720	559244..559873	-	630	WP_015433065.1	DsbA family oxidoreductase	-
F542_RS02725	559877..560329	-	453	WP_025266848.1	hypothetical protein	-
F542_RS02730	560563..561822	-	1260	WP_038445701.1	MFS transporter	-
F542_RS02735	562031..562435	+	405	Protein_540	ABC transporter ATP-binding protein	-
F542_RS10875	562573..562758	+	186	Protein_541	ATP-binding protein	-
F542_RS02740	562874..563128	+	255	WP_015433060.1	helix-turn-helix domain-containing protein	Antitoxin
F542_RS02745	563122..564408	+	1287	WP_015433059.1	type II toxin-antitoxin system HipA family toxin	Toxin
F542_RS02750	564480..564908	-	429	WP_015433058.1	helix-turn-helix domain-containing protein	-
F542_RS02755	565057..566058	+	1002	WP_015433057.1	TerC/Alx family metal homeostasis membrane protein	-
F542_RS02760	566059..566838	+	780	WP_015433056.1	hypothetical protein	-
F542_RS02765	566878..567453	+	576	WP_015433055.1	TerD family protein	-
F542_RS02770	567501..568175	+	675	WP_038445703.1	stress protein	-
F542_RS02775	568241..569389	-	1149	WP_015433053.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	543355..569389	26034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (148-394)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 429 a.a.
• Molecular weight: 48546.92 Da
• Isoelectric Point: 7.9839

>T45821 WP_015433059.1 NZ_CP006954:563122-564408 [Bibersteinia trehalosi USDA-ARS-USMARC-188]
MVGNVLTVAMNGLEVGHWQKLSSGATEFCYIPSWLNSPRKRAISLSLPLSDQIYRGDVVYNFFDNLLPDNELIRSRIQQR
FQTTTKSPFDLLSAIGQDCVGAIQLYNQTPSPTQNINAQKLVDQEIEHILQNYQSLPLGMAEQADFRISIAGAQEKTAFL
YHQGEWKRPLGSTPTTHIFKLPIGVVGQGQIDLSNSCENEWLCLNILRVFGLPVSQAEIAYFGETKVLIIERFDRRWAKD
NSYLLRLPQEDMCQAFNIAPARKYENDGGVGILPIMQLLKGSSNALADQKAFFKAQILFWLLCAIDGHAKNFSLFLEPNN
RYKLTPFYDVISAYPLISPKGLQKQKVKMAMAWHGEQNKHYLWDKIQLRHIFNTAKLAGLSKQTVEEILQEIVVASSRLN
SIPTQHLPEQIVDPILSEMERKLVVVNR

Nucleotide

• Length: 1287 bp

>T45821 NZ_CP006954:563122-564408 [Bibersteinia trehalosi USDA-ARS-USMARC-188]
ATGGTAGGCAATGTACTGACGGTTGCGATGAATGGGTTAGAAGTTGGGCATTGGCAAAAACTTTCTAGCGGAGCAACGGA
ATTTTGTTATATCCCGAGCTGGCTCAACTCTCCACGAAAACGAGCGATTTCTCTTTCATTACCGCTATCGGATCAAATTT
ATCGTGGTGATGTAGTCTATAATTTTTTCGATAATTTGTTGCCGGACAATGAATTAATTCGCTCCCGTATTCAGCAACGT
TTTCAAACCACCACAAAATCGCCGTTCGATTTGCTTTCGGCAATCGGGCAAGACTGTGTGGGAGCTATTCAGCTTTATAA
TCAAACACCTTCGCCCACTCAGAACATTAACGCTCAAAAGCTGGTAGATCAGGAAATTGAGCATATTTTACAAAATTATC
AAAGCCTGCCACTGGGTATGGCGGAGCAGGCAGATTTCCGTATTTCAATTGCTGGTGCGCAGGAAAAAACGGCCTTTCTT
TACCATCAAGGCGAATGGAAACGCCCGTTGGGTTCAACGCCAACCACACATATTTTCAAATTACCGATCGGTGTTGTTGG
ACAAGGGCAAATCGACCTTTCGAATAGTTGTGAAAATGAGTGGCTCTGTTTGAATATTTTGCGGGTATTTGGCTTGCCTG
TATCTCAGGCGGAAATTGCCTATTTTGGTGAAACCAAAGTGCTGATTATCGAACGTTTTGACCGCCGTTGGGCGAAGGAC
AATAGCTATTTGCTCCGTTTACCACAAGAAGATATGTGCCAAGCGTTTAACATTGCTCCGGCTCGGAAATATGAAAATGA
TGGTGGCGTTGGTATTCTGCCAATTATGCAACTCCTCAAAGGTTCGAGCAATGCACTTGCCGATCAAAAAGCCTTTTTCA
AAGCCCAAATTCTGTTTTGGCTGCTCTGTGCAATTGACGGACACGCCAAAAATTTCAGCCTATTTTTAGAACCTAACAAC
CGCTATAAACTTACGCCGTTTTACGATGTGATTTCCGCCTACCCATTGATTAGCCCGAAAGGCTTGCAAAAACAGAAAGT
TAAAATGGCAATGGCGTGGCACGGCGAGCAGAATAAGCACTATCTTTGGGATAAAATCCAACTTCGACATATTTTTAATA
CTGCAAAGTTAGCAGGCTTATCAAAACAGACAGTGGAGGAAATATTACAGGAGATTGTTGTGGCTTCATCACGATTAAAT
AGTATCCCGACACAACATTTGCCCGAACAAATTGTTGACCCGATTTTGAGTGAGATGGAGAGAAAGTTGGTTGTGGTGAA
TAGGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9528.92 Da
• Isoelectric Point: 4.7661

>AT45821 WP_015433060.1 NZ_CP006954:562874-563128 [Bibersteinia trehalosi USDA-ARS-USMARC-188]
MVATTPQMLAHAVKEYRNLQKKSQTEVATVANTKQSTISIFENDPTGTKIETLFNILMALELELVVQPRPKSRDILQDEE
GEIW

Nucleotide

• Length: 255 bp

>AT45821 NZ_CP006954:562874-563128 [Bibersteinia trehalosi USDA-ARS-USMARC-188]
ATGGTTGCTACCACGCCACAAATGTTGGCACACGCAGTGAAAGAATACCGTAACTTACAGAAAAAATCGCAAACTGAAGT
TGCCACAGTTGCTAACACTAAGCAATCGACGATCTCCATATTTGAAAATGATCCCACTGGCACAAAAATTGAAACTTTGT
TCAATATTTTAATGGCATTAGAATTAGAGTTAGTCGTCCAGCCTCGCCCGAAAAGTCGTGATATTTTGCAAGATGAAGAG
GGCGAGATATGGTAG

Structures

Toxin

• AlphaFold DB: A0A4V7I8D4