Detailed information of TA system TA045395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 3661904..3662426
• Replicon: chromosome
• Accession: NZ_CP006664
• Organism: Edwardsiella anguillarum ET080813 strain 80813

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: ETEE_RS16525
• Protein ID: WP_015871319.1
• Coordinates: 3661904..3662185 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: ETEE_RS16530
• Protein ID: WP_015871318.1
• Coordinates: 3662175..3662426 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETEE_RS16510	3657305..3658080	+	776	Protein_3286	hypothetical protein	-
ETEE_RS16515	3658073..3659734	+	1662	WP_049703944.1	terminase	-
ETEE_RS16520	3659731..3661832	+	2102	Protein_3288	portal protein	-
ETEE_RS16525	3661904..3662185	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETEE_RS16530	3662175..3662426	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ETEE_RS16535	3662714..3663181	+	468	Protein_3291	hypothetical protein	-
ETEE_RS16540	3663192..3663539	+	348	WP_144242832.1	hypothetical protein	-
ETEE_RS16545	3663911..3665785	+	1875	WP_034165826.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3629210..3689929	60719

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T45395 WP_015871319.1 NZ_CP006664:c3662185-3661904 [Edwardsiella anguillarum ET080813]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T45395 NZ_CP006664:c3662185-3661904 [Edwardsiella anguillarum ET080813]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCGCCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATTATCCTGCTGGTGATCGCGATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT45395 WP_015871318.1 NZ_CP006664:c3662426-3662175 [Edwardsiella anguillarum ET080813]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT45395 NZ_CP006664:c3662426-3662175 [Edwardsiella anguillarum ET080813]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGCAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCACTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3