Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2967128..2967720 Replicon chromosome
Accession NZ_CP006664
Organism Edwardsiella anguillarum ET080813 strain 80813

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag ETEE_RS13370 Protein ID WP_012847872.1
Coordinates 2967128..2967331 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag ETEE_RS13375 Protein ID WP_034163649.1
Coordinates 2967352..2967720 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETEE_RS13345 2962924..2963385 + 462 WP_034163655.1 Lrp/AsnC family transcriptional regulator -
ETEE_RS13350 2963663..2964001 + 339 WP_034163654.1 P-II family nitrogen regulator -
ETEE_RS13355 2964022..2965302 + 1281 WP_034163814.1 ammonium transporter AmtB -
ETEE_RS13360 2965337..2966203 - 867 WP_034163652.1 acyl-CoA thioesterase II -
ETEE_RS13365 2966312..2966641 - 330 WP_034163651.1 MGMT family protein -
ETEE_RS13370 2967128..2967331 - 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
ETEE_RS13375 2967352..2967720 - 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
ETEE_RS13380 2968087..2971239 - 3153 WP_034163648.1 multidrug efflux RND transporter permease subunit -
ETEE_RS13385 2971283..2972467 - 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T45394 WP_012847872.1 NZ_CP006664:c2967331-2967128 [Edwardsiella anguillarum ET080813]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T45394 NZ_CP006664:c2967331-2967128 [Edwardsiella anguillarum ET080813]
ATGACCAAGATCGATTATCTAATGAAGCTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAACTAGAAATTTTTTATTCTGCTGCAGATCATCGACTAGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCGGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT45394 WP_034163649.1 NZ_CP006664:c2967720-2967352 [Edwardsiella anguillarum ET080813]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT45394 NZ_CP006664:c2967720-2967352 [Edwardsiella anguillarum ET080813]
ATGGATGAGTATACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAACCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCGTCGCACAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATACTGGATGATTATCTG
GATGAAACCTACGCCCTGTTTGGTGCCTATAGCGTCAGTGAAACGGCGCTCAGACACTGGCTGCGTACCAAACGCCGTGT
GGCATACTGCCTGGCGCATGAAAAGCGCAATGCGGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References