Detailed information of TA system TA045245

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 1185315..1186057
• Replicon: chromosome
• Accession: NZ_CP006569
• Organism: Sodalis praecaptivus strain HS1

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: W0HQJ7
• Locus tag: SANT_RS05295
• Protein ID: WP_025421261.1
• Coordinates: 1185315..1185653 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: W0HUC2
• Locus tag: SANT_RS05300
• Protein ID: WP_025421262.1
• Coordinates: 1185692..1186057 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SANT_RS05285	1180640..1181599	-	960	WP_025421259.1	hypothetical protein	-
SANT_RS05290	1182315..1184138	-	1824	WP_025421260.1	hypothetical protein	-
SANT_RS05295	1185315..1185653	-	339	WP_025421261.1	TA system toxin CbtA family protein	Toxin
SANT_RS05300	1185692..1186057	-	366	WP_025421262.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
SANT_RS23220	1186083..1186304	-	222	WP_071881996.1	DUF987 domain-containing protein	-
SANT_RS05305	1186318..1186797	-	480	WP_025421263.1	DNA repair protein RadC	-
SANT_RS05310	1186809..1187252	-	444	WP_025421264.1	antirestriction protein	-
SANT_RS05315	1187265..1188104	-	840	WP_025421265.1	DUF945 domain-containing protein	-
SANT_RS23780	1188240..1189181	-	942	WP_025421266.1	hypothetical protein	-
SANT_RS22855	1189247..1189657	-	411	WP_025421267.1	hypothetical protein	-
SANT_RS05330	1189806..1190021	-	216	WP_025421268.1	hypothetical protein	-
SANT_RS24595	1190033..1190179	-	147	WP_171825048.1	hypothetical protein	-
SANT_RS05335	1190184..1190897	-	714	WP_025421269.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1174829..1211297	36468

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (17-117)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12841.61 Da
• Isoelectric Point: 6.8691

>T45245 WP_025421261.1 NZ_CP006569:c1185653-1185315 [Sodalis praecaptivus]
MQTISSRPTRATQPCLSPVEIWQQLLTHLLSQHYGLTLNDTPFSNETTIQEHIEAGVSLNDAVNFLVEKYGLVRIDRIGF
SWQEQTPYISVVDILRARRHIGLLKNQREINA

Nucleotide

• Length: 339 bp

>T45245 NZ_CP006569:c1185653-1185315 [Sodalis praecaptivus]
ATGCAAACCATATCATCACGCCCGACACGGGCGACTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGCAGCTGCTAAC
TCATCTGTTATCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGAAACCACCATTCAGGAACATATCG
AGGCAGGGGTATCTCTCAACGATGCGGTGAATTTCTTGGTCGAAAAATACGGGCTTGTCCGTATCGATCGGATAGGATTT
TCGTGGCAAGAGCAGACTCCGTACATTTCCGTAGTAGATATTTTGCGAGCAAGGCGCCATATCGGCTTGCTAAAAAACCA
ACGCGAGATAAACGCTTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13523.24 Da
• Isoelectric Point: 5.9556

>AT45245 WP_025421262.1 NZ_CP006569:c1186057-1185692 [Sodalis praecaptivus]
MNNHSVSGTTPEDTSCKHWGLKRSVTPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLISSE
LNPRYQHCVTLYHNGLTCEADTLGSCGYVYIAIYPEQTEPQ

Nucleotide

• Length: 366 bp

>AT45245 NZ_CP006569:c1186057-1185692 [Sodalis praecaptivus]
ATGAACAATCACTCTGTTTCCGGCACCACGCCGGAGGATACATCCTGCAAGCATTGGGGACTAAAACGCAGTGTCACACC
CTGTTTTGGCGCTCGCCTGGTGCAGGAAGGCAACCGGGTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACAACGATGCATTGCGCCTCGACCAGGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTGATTAGCAGCGAG
CTCAATCCCCGTTATCAGCACTGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTTTACATTGCTATCTATCCTGAGCAAACTGAGCCGCAGTAA

Structures

Toxin

• AlphaFold DB: W0HQJ7

Antitoxin

• AlphaFold DB: W0HUC2