Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 20840..21543 Replicon chromosome
Accession NZ_CP004887
Organism Klebsiella michiganensis HKOPL1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag J415_RS00095 Protein ID WP_038422859.1
Coordinates 20840..21181 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag J415_RS27550 Protein ID WP_071889540.1
Coordinates 21202..21543 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J415_RS00070 16539..17243 + 705 WP_014227723.1 DNA/RNA non-specific endonuclease -
J415_RS00075 17533..17856 + 324 WP_014227722.1 endoribonuclease SymE -
J415_RS00080 18003..18437 + 435 WP_004098173.1 VOC family protein -
J415_RS00085 18603..19346 + 744 WP_014227721.1 hypothetical protein -
J415_RS00090 19574..20581 - 1008 WP_038422858.1 restriction endonuclease -
J415_RS00095 20840..21181 - 342 WP_038422859.1 TA system toxin CbtA family protein Toxin
J415_RS27550 21202..21543 - 342 WP_071889540.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J415_RS00105 21554..22096 - 543 WP_017880113.1 DNA repair protein RadC -
J415_RS00110 22109..22549 - 441 WP_038422861.1 antirestriction protein -
J415_RS00115 22580..23401 - 822 WP_038422862.1 DUF945 domain-containing protein -
J415_RS00120 23500..23730 - 231 WP_038422863.1 DUF905 domain-containing protein -
J415_RS00125 23802..24251 - 450 WP_038422864.1 hypothetical protein -
J415_RS00130 24248..24700 - 453 WP_038422865.1 hypothetical protein -
J415_RS00135 24737..25305 - 569 Protein_26 hypothetical protein -
J415_RS27555 25305..26009 - 705 WP_071889541.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12675.68 Da        Isoelectric Point: 7.2429

>T45045 WP_038422859.1 NZ_CP004887:c21181-20840 [Klebsiella michiganensis HKOPL1]
MKTLPATTPQAATLCLSPVAVWQMLLACLLEQHYGLTLNDTPFSDETVILEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRHRISAAR

Download         Length: 342 bp

>T45045 NZ_CP004887:c21181-20840 [Klebsiella michiganensis HKOPL1]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTAGCAGTGTGGCAAATGCTGCTTGC
ATGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCTGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGACA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12840.34 Da        Isoelectric Point: 6.2084

>AT45045 WP_071889540.1 NZ_CP004887:c21543-21202 [Klebsiella michiganensis HKOPL1]
MKSTDSENDSFLKWGLNRNVTPFFGARLVQEGNRLHYLADRASISGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTHR

Download         Length: 342 bp

>AT45045 NZ_CP004887:c21543-21202 [Klebsiella michiganensis HKOPL1]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGGCTGAATCGTAATGTGACGCCTTTCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATCTGGCTGACCGGGCCAGCATTAGCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References