Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2103319..2103544 Replicon chromosome
Accession NZ_CP004057
Organism Shigella flexneri Shi06HN006 isolate Human

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag SFYV_RS11845 Protein ID WP_000813254.1
Coordinates 2103319..2103474 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2103486..2103544 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFYV_RS11790 2098631..2098981 - 351 WP_005048975.1 IS66 family insertion sequence element accessory protein TnpB -
SFYV_RS11795 2098978..2099652 - 675 WP_004967157.1 IS66-like element accessory protein TnpA -
SFYV_RS11800 2099751..2099966 - 216 WP_000839572.1 class II holin family protein -
SFYV_RS11825 2100762..2101450 - 689 Protein_2136 bacteriophage antitermination protein Q -
SFYV_RS11830 2101447..2101812 - 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
SFYV_RS11835 2101813..2102871 - 1059 WP_001265248.1 DUF968 domain-containing protein -
SFYV_RS26665 2102873..2103151 - 279 WP_011069426.1 hypothetical protein -
SFYV_RS11845 2103319..2103474 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 2103486..2103544 + 59 - - Antitoxin
SFYV_RS11855 2104126..2104542 - 417 WP_005069274.1 hypothetical protein -
SFYV_RS11860 2104569..2104709 + 141 Protein_2142 DUF4224 domain-containing protein -
SFYV_RS11865 2104709..2105759 + 1051 Protein_2143 tyrosine-type recombinase/integrase -
SFYV_RS11875 2105970..2106767 + 798 WP_001325918.1 DgsA anti-repressor MtfA -
SFYV_RS11885 2107105..2108367 + 1263 Protein_2145 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 2070133..2131958 61825


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T44949 WP_000813254.1 NZ_CP004057:c2103474-2103319 [Shigella flexneri Shi06HN006]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T44949 NZ_CP004057:c2103474-2103319 [Shigella flexneri Shi06HN006]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT44949 NZ_CP004057:2103486-2103544 [Shigella flexneri Shi06HN006]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References