Detailed information of TA system TA044938

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1438683..1438908
• Replicon: chromosome
• Accession: NZ_CP004057
• Organism: Shigella flexneri Shi06HN006 isolate Human

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: SFYV_RS07865
• Protein ID: WP_000813254.1
• Coordinates: 1438753..1438908 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1438683..1438741 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFYV_RS29260	1434681..1434850	+	170	Protein_1416	hypothetical protein	-
SFYV_RS07825	1434996..1435742	+	747	WP_000788996.1	ATP-binding protein	-
SFYV_RS07830	1435757..1436179	+	423	WP_001118168.1	DUF977 family protein	-
SFYV_RS07835	1436237..1436593	+	357	WP_005048249.1	hypothetical protein	-
SFYV_RS07840	1436686..1436904	+	219	WP_000256998.1	DUF4014 family protein	-
SFYV_RS07845	1436906..1437271	+	366	WP_001229297.1	HNH endonuclease signature motif containing protein	-
SFYV_RS07850	1437268..1437933	+	666	WP_000208062.1	hypothetical protein	-
SFYV_RS07855	1437933..1438298	+	366	WP_000610655.1	DUF551 domain-containing protein	-
-	1438683..1438741	-	59	-	-	Antitoxin
SFYV_RS07865	1438753..1438908	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
SFYV_RS07880	1440245..1440844	+	600	WP_000940329.1	DUF1367 family protein	-
SFYV_RS07885	1440844..1441134	+	291	WP_000228038.1	DUF1364 domain-containing protein	-
SFYV_RS07890	1441131..1441685	+	555	WP_000640143.1	DUF1133 family protein	-
SFYV_RS07895	1441838..1442011	+	174	WP_000504450.1	hypothetical protein	-
SFYV_RS26030	1442073..1443232	+	1160	WP_094106032.1	IS3-like element IS600 family transposase	-
SFYV_RS07910	1443260..1443628	+	369	WP_011069357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	ipaH9.8	1430766..1485653	54887

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T44938 WP_000813254.1 NZ_CP004057:1438753-1438908 [Shigella flexneri Shi06HN006]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T44938 NZ_CP004057:1438753-1438908 [Shigella flexneri Shi06HN006]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT44938 NZ_CP004057:c1438741-1438683 [Shigella flexneri Shi06HN006]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin