Detailed information of TA system TA044694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2350286..2350981
• Replicon: chromosome
• Accession: NZ_CP002882
• Organism: Mycobacterium tuberculosis BT2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HKBT2_RS11010
• Protein ID: WP_003905754.1
• Coordinates: 2350286..2350720 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: HKBT2_RS11015
• Protein ID: WP_003410814.1
• Coordinates: 2350727..2350981 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HKBT2_RS11000	2346440..2349481	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
HKBT2_RS11005	2349474..2350307	+	834	WP_003899172.1	SWIM zinc finger family protein	-
HKBT2_RS11010	2350286..2350720	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
HKBT2_RS11015	2350727..2350981	-	255	WP_003410814.1	antitoxin	Antitoxin
HKBT2_RS11020	2350997..2351254	-	258	WP_003410816.1	hypothetical protein	-
HKBT2_RS11030	2351788..2353049	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
HKBT2_RS11035	2353559..2353855	+	297	WP_003410820.1	PE family protein	-
HKBT2_RS11040	2353911..2354642	+	732	WP_003900467.1	PPE family protein	-
HKBT2_RS11045	2355182..2355928	-	747	WP_003901330.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T44694 WP_003905754.1 NZ_CP002882:c2350720-2350286 [Mycobacterium tuberculosis BT2]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T44694 NZ_CP002882:c2350720-2350286 [Mycobacterium tuberculosis BT2]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT44694 WP_003410814.1 NZ_CP002882:c2350981-2350727 [Mycobacterium tuberculosis BT2]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT44694 NZ_CP002882:c2350981-2350727 [Mycobacterium tuberculosis BT2]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0