Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 223306..223889 Replicon chromosome
Accession NZ_AP028062
Organism Marinobacter shengliensis strain D49

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QUE75_RS00960 Protein ID WP_072678787.1
Coordinates 223701..223889 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QUE75_RS00955 Protein ID WP_138437307.1
Coordinates 223306..223698 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE75_RS00945 (MAALD49_01870) 219918..222593 + 2676 WP_286253044.1 nitrate reductase -
QUE75_RS00950 (MAALD49_01880) 222601..223257 - 657 WP_286253045.1 hypothetical protein -
QUE75_RS00955 (MAALD49_01890) 223306..223698 - 393 WP_138437307.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QUE75_RS00960 (MAALD49_01900) 223701..223889 - 189 WP_072678787.1 type II toxin-antitoxin system HicA family toxin Toxin
QUE75_RS00965 (MAALD49_01910) 224006..224524 - 519 WP_286253048.1 Hcp family type VI secretion system effector -
QUE75_RS00970 (MAALD49_01920) 224729..226459 - 1731 WP_286253050.1 bifunctional protein-serine/threonine kinase/phosphatase -
QUE75_RS00975 (MAALD49_01930) 226456..227292 - 837 WP_058092825.1 formate/nitrite transporter family protein -
QUE75_RS00980 (MAALD49_01940) 227589..228329 - 741 WP_286253053.1 energy transducer TonB -
QUE75_RS00985 (MAALD49_01950) 228326..228736 - 411 WP_138437304.1 biopolymer transporter ExbD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-123)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7149.25 Da        Isoelectric Point: 10.8393

>T44458 WP_072678787.1 NZ_AP028062:c223889-223701 [Marinobacter shengliensis]
VKSAELIRRLKAEGWAKVGGKGDHEKYKHPDKPGHVVVPHPRKDIPIGTLRNIYRQAGWDWR

Download         Length: 189 bp

>T44458 NZ_AP028062:c223889-223701 [Marinobacter shengliensis]
GTGAAGAGTGCTGAACTGATTAGACGACTCAAAGCTGAAGGCTGGGCCAAAGTCGGTGGCAAGGGAGATCACGAAAAATA
TAAGCATCCGGACAAACCGGGGCATGTTGTGGTTCCGCACCCCCGCAAAGATATTCCCATCGGCACCCTGAGAAACATTT
ATCGCCAGGCCGGGTGGGATTGGAGGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14852.71 Da        Isoelectric Point: 4.4267

>AT44458 WP_138437307.1 NZ_AP028062:c223698-223306 [Marinobacter shengliensis]
VLYPVYVHKGDDEHAHGAEIPDFPGCFSAADQWQELPGKIQEAIELYCEDEDMELPQPSSLDDLMNNPDYQGGLWMMVDI
DVNRLKTRAVRLNVSLPEGLLRRIDEEARSRHMSRSAFLAMTARKELEAH

Download         Length: 393 bp

>AT44458 NZ_AP028062:c223698-223306 [Marinobacter shengliensis]
GTGCTTTATCCCGTATACGTGCACAAGGGCGACGACGAGCACGCTCACGGCGCCGAAATTCCGGATTTCCCCGGCTGTTT
TTCCGCTGCTGATCAGTGGCAGGAGTTACCGGGCAAAATTCAGGAAGCCATTGAACTGTATTGCGAAGATGAGGACATGG
AGCTGCCGCAGCCTTCCTCGCTGGATGACCTGATGAACAATCCGGATTATCAGGGCGGCCTCTGGATGATGGTCGATATC
GACGTTAACCGCTTGAAAACCAGAGCTGTCCGTCTTAACGTCAGCCTTCCGGAAGGGTTGTTGCGCCGTATAGACGAAGA
GGCCCGAAGCAGACATATGAGCCGGTCGGCATTTCTGGCAATGACGGCCCGCAAAGAACTGGAAGCCCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References