Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 36737..37272 | Replicon | plasmid pVE-T2_1 |
| Accession | NZ_AP027961 | ||
| Organism | Escherichia coli strain VE-T2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q3YTD6 |
| Locus tag | QQK13_RS23995 | Protein ID | WP_000222766.1 |
| Coordinates | 36737..37024 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0VIP2 |
| Locus tag | QQK13_RS24000 | Protein ID | WP_001132900.1 |
| Coordinates | 37021..37272 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQK13_RS23965 (32285) | 32285..33145 | - | 861 | WP_000557454.1 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
| QQK13_RS23970 (33288) | 33288..33782 | + | 495 | Protein_38 | IS4-like element ISVsa5 family transposase | - |
| QQK13_RS23975 (33836) | 33836..34540 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| QQK13_RS23980 (34608) | 34608..35906 | + | 1299 | Protein_40 | Tn3-like element Tn3 family transposase | - |
| QQK13_RS23985 (35940) | 35940..36440 | + | 501 | Protein_41 | Tn3 family transposase | - |
| QQK13_RS23990 (36474) | 36474..36662 | + | 189 | Protein_42 | IS3 family transposase | - |
| QQK13_RS23995 (36737) | 36737..37024 | - | 288 | WP_000222766.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QQK13_RS24000 (37021) | 37021..37272 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| QQK13_RS24005 (38238) | 38238..39095 | - | 858 | WP_039002220.1 | incFII family plasmid replication initiator RepA | - |
| QQK13_RS24010 (39088) | 39088..39162 | - | 75 | WP_061357229.1 | RepA leader peptide Tap | - |
| QQK13_RS24015 (39394) | 39394..39651 | - | 258 | WP_001541895.1 | replication regulatory protein RepA | - |
| QQK13_RS24020 (39919) | 39919..40068 | - | 150 | WP_001312851.1 | Hok/Gef family protein | - |
| - (40112) | 40112..40173 | + | 62 | NuclAT_0 | - | - |
| - (40112) | 40112..40173 | + | 62 | NuclAT_0 | - | - |
| - (40112) | 40112..40173 | + | 62 | NuclAT_0 | - | - |
| - (40112) | 40112..40173 | + | 62 | NuclAT_0 | - | - |
| QQK13_RS24025 (40515) | 40515..40727 | - | 213 | WP_001541896.1 | ANR family transcriptional regulator | - |
| QQK13_RS24030 (40862) | 40862..41422 | - | 561 | WP_000139310.1 | fertility inhibition protein FinO | - |
| QQK13_RS24035 (41477) | 41477..42091 | - | 615 | Protein_51 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / floR / sul2 / aac(3)-IId / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..88388 | 88388 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11147.23 Da Isoelectric Point: 10.5832
>T44295 WP_000222766.1 NZ_AP027961:c37024-36737 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
Download Length: 288 bp
>T44295 NZ_AP027961:c37024-36737 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9211.41 Da Isoelectric Point: 4.0780
>AT44295 WP_001132900.1 NZ_AP027961:c37272-37021 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
Download Length: 252 bp
>AT44295 NZ_AP027961:c37272-37021 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CDZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0VIP2 |