Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4062552..4062810 Replicon chromosome
Accession NZ_AP027957
Organism Escherichia coli strain VE-T10

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag QQK14_RS19820 Protein ID WP_000809168.1
Coordinates 4062658..4062810 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4062552..4062609 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQK14_RS19800 4057600..4058931 + 1332 Protein_3877 fimbria/pilus outer membrane usher protein -
QQK14_RS19805 4058944..4059902 + 959 Protein_3878 fimbrial family protein -
QQK14_RS19810 4059941..4060840 - 900 WP_001300855.1 transcriptional activator NhaR -
QQK14_RS19815 4060906..4062072 - 1167 WP_000681368.1 Na+/H+ antiporter NhaA -
- 4062552..4062609 - 58 - - Antitoxin
QQK14_RS19820 4062658..4062810 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
QQK14_RS19825 4062914..4064044 - 1131 WP_001118464.1 molecular chaperone DnaJ -
QQK14_RS19830 4064133..4066049 - 1917 WP_000516135.1 molecular chaperone DnaK -
QQK14_RS19835 4066426..4066830 + 405 WP_000843559.1 DUF2541 family protein -
QQK14_RS19840 4066856..4067569 + 714 WP_001102379.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T44260 WP_000809168.1 NZ_AP027957:4062658-4062810 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T44260 NZ_AP027957:4062658-4062810 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTAGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT44260 NZ_AP027957:c4062609-4062552 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References