Detailed information of TA system TA044177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4384833..4385355
• Replicon: chromosome
• Accession: NZ_AP027926
• Organism: Escherichia fergusonii strain 30038

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: QUE84_RS21170
• Protein ID: WP_222702029.1
• Coordinates: 4384833..4385123 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V0SC69
• Locus tag: QUE84_RS21175
• Protein ID: WP_000212715.1
• Coordinates: 4385113..4385355 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE84_RS21155 (4380046)	4380046..4381701	+	1656	WP_222702027.1	alpha,alpha-phosphotrehalase	-
QUE84_RS21160 (4382095)	4382095..4384233	+	2139	WP_000187805.1	anaerobic ribonucleoside-triphosphate reductase	-
QUE84_RS21165 (4384368)	4384368..4384832	+	465	WP_222702028.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
QUE84_RS21170 (4384833)	4384833..4385123	-	291	WP_222702029.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUE84_RS21175 (4385113)	4385113..4385355	-	243	WP_000212715.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
QUE84_RS21180 (4385546)	4385546..4385932	-	387	WP_001232246.1	cytochrome b562	-
QUE84_RS21185 (4385985)	4385985..4387337	-	1353	WP_001162171.1	metalloprotease PmbA	-
QUE84_RS21190 (4387431)	4387431..4387982	+	552	WP_000166270.1	ribosome biogenesis factor YjgA	-
QUE84_RS21195 (4388065)	4388065..4389438	-	1374	WP_001219809.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11280.20 Da
• Isoelectric Point: 10.1701

>T44177 WP_222702029.1 NZ_AP027926:c4385123-4384833 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T44177 NZ_AP027926:c4385123-4384833 [Escherichia fergusonii]
ATGAACTATGAACTGGCTTTTGATCCGCGGGCGCTGAAGGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGGGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTACGGGATTTGCCGGACTGCTACAAAATTA
AGCTTCGCACACTGGGATATCGCCTGGTCTATCAGGTCAATGATAAAGAGTTACTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9125.56 Da
• Isoelectric Point: 5.1369

>AT44177 WP_000212715.1 NZ_AP027926:c4385355-4385113 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT44177 NZ_AP027926:c4385355-4385113 [Escherichia fergusonii]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAGGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A7U9H4B3