Detailed information of TA system TA044140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 3709232..3709800
• Replicon: chromosome
• Accession: NZ_AP027732
• Organism: Frondihabitans sucicola strain NBRC 108728

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: QUE79_RS19015
• Protein ID: WP_286344429.1
• Coordinates: 3709232..3709612 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: QUE79_RS19020
• Protein ID: WP_286344430.1
• Coordinates: 3709609..3709800 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE79_RS18990 (GCM10025867_39690)	3704515..3705537	-	1023	WP_286344424.1	zinc-dependent alcohol dehydrogenase family protein	-
QUE79_RS18995 (GCM10025867_39700)	3705635..3706036	-	402	WP_286344425.1	cupin domain-containing protein	-
QUE79_RS19000 (GCM10025867_39710)	3706033..3706950	-	918	WP_286344426.1	helix-turn-helix transcriptional regulator	-
QUE79_RS19005 (GCM10025867_39720)	3707050..3708426	+	1377	WP_286344427.1	MFS transporter	-
QUE79_RS19010 (GCM10025867_39730)	3708907..3709131	+	225	WP_286344428.1	hypothetical protein	-
QUE79_RS19015 (GCM10025867_39740)	3709232..3709612	-	381	WP_286344429.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
QUE79_RS19020 (GCM10025867_39750)	3709609..3709800	-	192	WP_286344430.1	antitoxin Phd	Antitoxin
QUE79_RS19025 (GCM10025867_39760)	3709913..3710056	-	144	WP_286344431.1	hypothetical protein	-
QUE79_RS19030 (GCM10025867_39770)	3710660..3711118	-	459	WP_286344432.1	hypothetical protein	-
QUE79_RS19035 (GCM10025867_39780)	3711174..3711587	+	414	WP_286344433.1	hypothetical protein	-
QUE79_RS19040 (GCM10025867_39790)	3711627..3712208	-	582	WP_286344434.1	hypothetical protein	-
QUE79_RS19045 (GCM10025867_39810)	3712311..3712577	+	267	WP_286344435.1	hypothetical protein	-
QUE79_RS19050 (GCM10025867_39820)	3712594..3713208	-	615	WP_286344436.1	hypothetical protein	-
QUE79_RS19055	3713219..3713371	-	153	WP_286344437.1	hypothetical protein	-
QUE79_RS19060 (GCM10025867_39840)	3713895..3714737	-	843	WP_286344438.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3709232..3719684	10452

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (23-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13263.88 Da
• Isoelectric Point: 4.2090

>T44140 WP_286344429.1 NZ_AP027732:c3709612-3709232 [Frondihabitans sucicola]
VTTYFLDRDDVLTAGSAAFGGTLAVRDFGLLDAAVARPRTSVFGIDAYADLWLKAAALLHSLARNHALVDGNKRTAWAAA
WVFLGVNGVTLDPGFDVDAAYDFVVDAATGALEVDDIARALESFAS

Nucleotide

• Length: 381 bp

>T44140 NZ_AP027732:c3709612-3709232 [Frondihabitans sucicola]
GTGACGACGTACTTCCTTGACCGCGACGATGTGCTGACCGCTGGCTCGGCGGCCTTCGGTGGCACATTGGCCGTCCGCGA
CTTCGGGCTTCTCGACGCCGCGGTGGCTCGGCCGCGCACGAGCGTCTTCGGCATCGACGCGTATGCGGACCTCTGGCTGA
AGGCCGCCGCGTTGCTGCACTCGTTGGCACGCAATCACGCTCTCGTCGACGGCAACAAGCGCACGGCGTGGGCGGCGGCG
TGGGTGTTCCTCGGTGTCAACGGCGTGACGCTTGATCCGGGCTTCGACGTCGACGCGGCGTACGACTTCGTGGTCGACGC
CGCAACCGGTGCCCTTGAGGTAGACGACATTGCGCGAGCGCTGGAGTCGTTCGCCTCCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 6757.60 Da
• Isoelectric Point: 5.7262

>AT44140 WP_286344430.1 NZ_AP027732:c3709800-3709609 [Frondihabitans sucicola]
MPSLNVTFTEAELEEIRTASAETSLKSYVHDQALSAARNRKALVAQLAQQVAATSAELNARLA

Nucleotide

• Length: 192 bp

>AT44140 NZ_AP027732:c3709800-3709609 [Frondihabitans sucicola]
ATGCCTTCGCTCAACGTCACGTTCACAGAAGCCGAGCTCGAAGAGATCCGCACAGCTTCGGCTGAGACATCCCTGAAGTC
CTACGTGCACGACCAGGCCCTGAGCGCCGCGCGGAATCGCAAGGCTCTGGTGGCTCAGCTGGCGCAGCAGGTCGCGGCTA
CGTCCGCGGAGCTGAACGCACGTCTCGCGTGA