Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3440127..3440820 Replicon chromosome
Accession NZ_AP027258
Organism Escherichia coli strain JNE151685

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QUE29_RS16965 Protein ID WP_000415584.1
Coordinates 3440524..3440820 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QUE29_RS16960 Protein ID WP_000650107.1
Coordinates 3440127..3440522 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE29_RS16950 (3435991) 3435991..3438249 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
QUE29_RS16955 (3438387) 3438387..3439994 - 1608 WP_097753825.1 ABC transporter substrate-binding protein -
QUE29_RS16960 (3440127) 3440127..3440522 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QUE29_RS16965 (3440524) 3440524..3440820 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QUE29_RS16970 (3441025) 3441025..3441507 - 483 WP_000183494.1 GyrI-like domain-containing protein -
QUE29_RS16975 (3441560) 3441560..3441952 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QUE29_RS16980 (3442104) 3442104..3442763 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
QUE29_RS16985 (3442760) 3442760..3444109 + 1350 WP_053889563.1 quorum sensing histidine kinase QseC -
QUE29_RS16990 (3444219) 3444219..3444800 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QUE29_RS16995 (3444831) 3444831..3445145 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T43655 WP_000415584.1 NZ_AP027258:c3440820-3440524 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T43655 NZ_AP027258:c3440820-3440524 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT43655 WP_000650107.1 NZ_AP027258:c3440522-3440127 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT43655 NZ_AP027258:c3440522-3440127 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References