Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1519806..1520604 Replicon chromosome
Accession NZ_AP027206
Organism Escherichia coli strain JNE082640

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag QUE04_RS07295 Protein ID WP_000854902.1
Coordinates 1519806..1520183 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag QUE04_RS07300 Protein ID WP_001280952.1
Coordinates 1520230..1520604 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE04_RS07265 (1515152) 1515152..1516129 + 978 WP_000633238.1 type II secretion system minor pseudopilin GspK -
QUE04_RS07270 (1516126) 1516126..1517304 + 1179 WP_000094974.1 type II secretion system protein GspL -
QUE04_RS07275 (1517306) 1517306..1517842 + 537 WP_000942798.1 GspM family type II secretion system protein YghD -
QUE04_RS07280 (1518185) 1518185..1519027 - 843 WP_001280537.1 DUF4942 domain-containing protein -
QUE04_RS07285 (1519112) 1519112..1519309 - 198 WP_000839249.1 DUF957 domain-containing protein -
QUE04_RS07290 (1519321) 1519321..1519809 - 489 WP_000779175.1 DUF5983 family protein -
QUE04_RS07295 (1519806) 1519806..1520183 - 378 WP_000854902.1 TA system toxin CbtA family protein Toxin
QUE04_RS07300 (1520230) 1520230..1520604 - 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QUE04_RS07305 (1520767) 1520767..1520988 - 222 WP_000692312.1 DUF987 domain-containing protein -
QUE04_RS07310 (1521051) 1521051..1521527 - 477 WP_001186725.1 RadC family protein -
QUE04_RS07315 (1521543) 1521543..1522028 - 486 WP_000849590.1 antirestriction protein -
QUE04_RS07320 (1522083) 1522083..1522901 - 819 WP_001234626.1 DUF932 domain-containing protein -
QUE04_RS07325 (1523001) 1523001..1523234 - 234 WP_001119729.1 DUF905 family protein -
QUE04_RS07330 (1523313) 1523313..1523768 - 456 WP_000581507.1 IrmA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM 1405135..1593065 187930


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-118)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14307.29 Da        Isoelectric Point: 7.2922

>T43486 WP_000854902.1 NZ_AP027206:c1520183-1519806 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T43486 NZ_AP027206:c1520183-1519806 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT43486 WP_001280952.1 NZ_AP027206:c1520604-1520230 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT43486 NZ_AP027206:c1520604-1520230 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References