Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5607239..5608071 Replicon chromosome
Accession NZ_AP027197
Organism Escherichia coli strain 02E060

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag QMG97_RS28670 Protein ID WP_000854753.1
Coordinates 5607697..5608071 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag QMG97_RS28665 Protein ID WP_001315620.1
Coordinates 5607239..5607607 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG97_RS28635 (5604075) 5604075..5604530 + 456 WP_000581504.1 IrmA family protein -
QMG97_RS28640 (5604609) 5604609..5604842 + 234 WP_001119729.1 DUF905 family protein -
QMG97_RS28645 (5604942) 5604942..5605760 + 819 WP_001234622.1 DUF932 domain-containing protein -
QMG97_RS28650 (5605815) 5605815..5606300 + 486 WP_000849588.1 antirestriction protein -
QMG97_RS28655 (5606316) 5606316..5606792 + 477 WP_001186774.1 RadC family protein -
QMG97_RS28660 (5606855) 5606855..5607076 + 222 WP_000692345.1 DUF987 domain-containing protein -
QMG97_RS28665 (5607239) 5607239..5607607 + 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG97_RS28670 (5607697) 5607697..5608071 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
QMG97_RS28675 (5608068) 5608068..5608556 + 489 WP_000777547.1 DUF5983 family protein -
QMG97_RS28680 (5608568) 5608568..5608765 + 198 WP_000839281.1 DUF957 domain-containing protein -
QMG97_RS28685 (5608850) 5608850..5608999 + 150 Protein_5603 restriction endonuclease subunit M -
QMG97_RS28690 (5609767) 5609767..5609910 - 144 Protein_5604 HNH endonuclease -
QMG97_RS28695 (5610047) 5610047..5610697 + 651 WP_001037966.1 HNH endonuclease -
QMG97_RS28700 (5610705) 5610705..5611685 - 981 WP_000991415.1 sialate O-acetylesterase -
QMG97_RS28705 (5611750) 5611750..5612856 - 1107 WP_001341302.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T43468 WP_000854753.1 NZ_AP027197:5607697-5608071 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T43468 NZ_AP027197:5607697-5608071 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT43468 WP_001315620.1 NZ_AP027197:5607239-5607607 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT43468 NZ_AP027197:5607239-5607607 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0


Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References