Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2815431..2816266 Replicon chromosome
Accession NZ_AP027197
Organism Escherichia coli strain 02E060

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag QMG97_RS14890 Protein ID WP_000854757.1
Coordinates 2815889..2816266 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag QMG97_RS14885 Protein ID WP_001295723.1
Coordinates 2815431..2815799 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG97_RS14845 (2811538) 2811538..2811885 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
QMG97_RS14850 (2811882) 2811882..2812286 - 405 WP_000839179.1 transposase -
QMG97_RS14855 (2812366) 2812366..2812716 + 351 Protein_2910 IrmA family protein -
QMG97_RS14860 (2812795) 2812795..2813028 + 234 WP_001119729.1 DUF905 family protein -
QMG97_RS14865 (2813128) 2813128..2813946 + 819 WP_001234620.1 DUF932 domain-containing protein -
QMG97_RS14870 (2814001) 2814001..2814486 + 486 WP_000849582.1 antirestriction protein -
QMG97_RS14875 (2814502) 2814502..2814978 + 477 WP_001186725.1 RadC family protein -
QMG97_RS14880 (2815047) 2815047..2815268 + 222 WP_000692323.1 DUF987 domain-containing protein -
QMG97_RS14885 (2815431) 2815431..2815799 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG97_RS14890 (2815889) 2815889..2816266 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
QMG97_RS14895 (2816263) 2816263..2816412 + 150 Protein_2918 DUF5983 family protein -
QMG97_RS14900 (2816512) 2816512..2816592 + 81 Protein_2919 hypothetical protein -
QMG97_RS14905 (2817408) 2817408..2817779 + 372 WP_001295631.1 IS110 family transposase -
QMG97_RS14910 (2818050) 2818050..2818415 + 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
QMG97_RS14915 (2818516) 2818516..2818845 - 330 WP_000450409.1 DUF496 family protein -
QMG97_RS14920 (2819017) 2819017..2820075 - 1059 WP_001200887.1 FUSC family protein -
QMG97_RS14925 (2820273) 2820273..2820746 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T43458 WP_000854757.1 NZ_AP027197:2815889-2816266 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T43458 NZ_AP027197:2815889-2816266 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT43458 WP_001295723.1 NZ_AP027197:2815431-2815799 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT43458 NZ_AP027197:2815431-2815799 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References