Detailed information of TA system TA043428

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5758005..5758417
• Replicon: chromosome
• Accession: NZ_AP027191
• Organism: Escherichia coli strain 10153

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: QMG89_RS29695
• Protein ID: WP_000132621.1
• Coordinates: 5758005..5758346 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5758341..5758417 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG89_RS29675 (5754015)	5754015..5755427	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
QMG89_RS29680 (5755604)	5755604..5755768	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
QMG89_RS29685 (5755865)	5755865..5756747	+	883	Protein_5800	DUF262 domain-containing protein	-
QMG89_RS29690 (5756795)	5756795..5757958	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
QMG89_RS29695 (5758005)	5758005..5758346	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (5758341)	5758341..5758417	+	77	NuclAT_28	-	Antitoxin
- (5758341)	5758341..5758417	+	77	NuclAT_28	-	Antitoxin
- (5758341)	5758341..5758417	+	77	NuclAT_28	-	Antitoxin
- (5758341)	5758341..5758417	+	77	NuclAT_28	-	Antitoxin
- (5758341)	5758341..5758417	+	77	NuclAT_29	-	Antitoxin
- (5758341)	5758341..5758417	+	77	NuclAT_29	-	Antitoxin
- (5758341)	5758341..5758417	+	77	NuclAT_29	-	Antitoxin
- (5758341)	5758341..5758417	+	77	NuclAT_29	-	Antitoxin
QMG89_RS29700 (5758567)	5758567..5760336	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
QMG89_RS29705 (5760336)	5760336..5761805	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T43428 WP_000132621.1 NZ_AP027191:c5758346-5758005 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T43428 NZ_AP027191:c5758346-5758005 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT43428 NZ_AP027191:5758341-5758417 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin