Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ypjF-yeeU/CbtA-CbeA |
| Location | 4288301..4289076 | Replicon | chromosome |
| Accession | NZ_AP026907 | ||
| Organism | Escherichia coli strain MY732 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A7V7JG91 |
| Locus tag | MY015_RS20885 | Protein ID | WP_001193488.1 |
| Coordinates | 4288301..4288672 (-) | Length | 124 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7V7JFU6 |
| Locus tag | MY015_RS20890 | Protein ID | WP_001059301.1 |
| Coordinates | 4288711..4289076 (-) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MY015_RS20860 (4283383) | 4283383..4284489 | + | 1107 | WP_001044128.1 | N-acetylneuraminate epimerase | - |
| MY015_RS20865 (4284554) | 4284554..4285534 | + | 981 | WP_001366032.1 | sialate O-acetylesterase | - |
| MY015_RS20870 (4285542) | 4285542..4285646 | - | 105 | Protein_4087 | HNH endonuclease | - |
| MY015_RS20875 (4285746) | 4285746..4286618 | + | 873 | WP_000168567.1 | HNH endonuclease | - |
| MY015_RS20880 (4286729) | 4286729..4287727 | - | 999 | WP_001240355.1 | membrane protein | - |
| MY015_RS20885 (4288301) | 4288301..4288672 | - | 372 | WP_001193488.1 | TA system toxin CbtA family protein | Toxin |
| MY015_RS20890 (4288711) | 4288711..4289076 | - | 366 | WP_001059301.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MY015_RS20895 (4289102) | 4289102..4289323 | - | 222 | WP_000691983.1 | DUF987 domain-containing protein | - |
| MY015_RS20900 (4289320) | 4289320..4289862 | - | 543 | WP_015740440.1 | DNA repair protein RadC | - |
| MY015_RS20905 (4289875) | 4289875..4290318 | - | 444 | WP_001096016.1 | antirestriction protein | - |
| MY015_RS20910 (4290349) | 4290349..4291170 | - | 822 | WP_001234409.1 | DUF932 domain-containing protein | - |
| MY015_RS20915 (4291290) | 4291290..4291763 | - | 474 | WP_001298943.1 | hypothetical protein | - |
| MY015_RS20920 (4291835) | 4291835..4292287 | - | 453 | WP_000734321.1 | hypothetical protein | - |
| MY015_RS20925 (4292323) | 4292323..4293039 | - | 717 | WP_000174910.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimE / fimB | 4279516..4295816 | 16300 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13832.94 Da Isoelectric Point: 7.2419
>T42827 WP_001193488.1 NZ_AP026907:c4288672-4288301 [Escherichia coli]
MQTISSHPTRATQPCLSPVEIWQRLLTCLLSQHYGLTLNDTPFSNETTILEHIDAGVSLCDAVNFLVEKYELVRIDCNDC
SVMEKSPFITSIDILRARKASGLMKRNSHKTVTRVTAGRLQEL
MQTISSHPTRATQPCLSPVEIWQRLLTCLLSQHYGLTLNDTPFSNETTILEHIDAGVSLCDAVNFLVEKYELVRIDCNDC
SVMEKSPFITSIDILRARKASGLMKRNSHKTVTRVTAGRLQEL
Download Length: 372 bp
>T42827 NZ_AP026907:c4288672-4288301 [Escherichia coli]
ATGCAAACTATATCATCACACCCGACACGGGCGACTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGCGGTTACTGAC
TTGTCTGTTGTCGCAGCACTATGGTCTGACGTTGAATGACACACCGTTCAGTAATGAAACCACCATACTGGAACACATTG
ATGCTGGAGTATCGCTGTGCGATGCGGTGAACTTTCTTGTTGAAAAATATGAACTGGTAAGAATTGACTGTAATGATTGC
TCTGTCATGGAGAAGTCACCGTTCATCACCAGTATCGATATTCTACGTGCCCGGAAAGCCTCCGGTCTGATGAAACGCAA
CAGTCACAAAACTGTTACCAGGGTAACGGCAGGTCGACTTCAGGAGCTATAA
ATGCAAACTATATCATCACACCCGACACGGGCGACTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGCGGTTACTGAC
TTGTCTGTTGTCGCAGCACTATGGTCTGACGTTGAATGACACACCGTTCAGTAATGAAACCACCATACTGGAACACATTG
ATGCTGGAGTATCGCTGTGCGATGCGGTGAACTTTCTTGTTGAAAAATATGAACTGGTAAGAATTGACTGTAATGATTGC
TCTGTCATGGAGAAGTCACCGTTCATCACCAGTATCGATATTCTACGTGCCCGGAAAGCCTCCGGTCTGATGAAACGCAA
CAGTCACAAAACTGTTACCAGGGTAACGGCAGGTCGACTTCAGGAGCTATAA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13388.25 Da Isoelectric Point: 5.9530
>AT42827 WP_001059301.1 NZ_AP026907:c4289076-4288711 [Escherichia coli]
MNNHSESGTKPENPACQQWGLKCAITPCFGARLVQEGNRLHFLSDRAGFSGAFAVDVAMRLDQAFPLMMKQLELMLTSGE
LNPRHPHCVTLYHNGLTCEADTLGSCGYVYIAIYPEQTEPQ
MNNHSESGTKPENPACQQWGLKCAITPCFGARLVQEGNRLHFLSDRAGFSGAFAVDVAMRLDQAFPLMMKQLELMLTSGE
LNPRHPHCVTLYHNGLTCEADTLGSCGYVYIAIYPEQTEPQ
Download Length: 366 bp
>AT42827 NZ_AP026907:c4289076-4288711 [Escherichia coli]
ATGAACAATCACTCAGAATCCGGTACAAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGGCTTAAATGTGCTATTACCCC
CTGTTTTGGTGCCCGCCTGGTACAGGAGGGCAACCGATTGCATTTTCTCTCTGACCGCGCAGGATTTAGCGGGGCATTTG
CCGTCGATGTTGCAATGCGCCTTGACCAGGCATTTCCGTTAATGATGAAGCAACTTGAGCTGATGCTGACCAGTGGAGAG
CTTAACCCTCGCCACCCACACTGCGTCACGCTTTACCACAATGGACTCACCTGTGAAGCCGATACACTAGGCTCCTGTGG
TTATGTCTACATTGCTATCTATCCTGAGCAAACTGAGCCGCAGTAA
ATGAACAATCACTCAGAATCCGGTACAAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGGCTTAAATGTGCTATTACCCC
CTGTTTTGGTGCCCGCCTGGTACAGGAGGGCAACCGATTGCATTTTCTCTCTGACCGCGCAGGATTTAGCGGGGCATTTG
CCGTCGATGTTGCAATGCGCCTTGACCAGGCATTTCCGTTAATGATGAAGCAACTTGAGCTGATGCTGACCAGTGGAGAG
CTTAACCCTCGCCACCCACACTGCGTCACGCTTTACCACAATGGACTCACCTGTGAAGCCGATACACTAGGCTCCTGTGG
TTATGTCTACATTGCTATCTATCCTGAGCAAACTGAGCCGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7V7JG91 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7V7JFU6 |