Detailed information of TA system TA042771

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 523926..524442
• Replicon: chromosome
• Accession: NZ_AP026873
• Organism: Enterobacter roggenkampii strain KAM546

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OO938_RS02530
• Protein ID: WP_264882164.1
• Coordinates: 524158..524442 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: OO938_RS02525
• Protein ID: WP_008501400.1
• Coordinates: 523926..524168 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO938_RS02510 (KAM546c_04960)	520016..520756	+	741	WP_023326574.1	KDGP aldolase family protein	-
OO938_RS02515 (KAM546c_04970)	520782..521918	+	1137	WP_264882162.1	lactonase family protein	-
OO938_RS02520 (KAM546c_04980)	521938..523848	+	1911	WP_008501401.1	PRD domain-containing protein	-
OO938_RS02525 (KAM546c_04990)	523926..524168	+	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OO938_RS02530 (KAM546c_05000)	524158..524442	+	285	WP_264882164.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO938_RS02535 (KAM546c_05010)	524446..524910	-	465	WP_264882166.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
OO938_RS02540 (KAM546c_05020)	525016..527154	-	2139	WP_008501397.1	anaerobic ribonucleoside-triphosphate reductase	-
OO938_RS02545 (KAM546c_05030)	527531..529174	-	1644	WP_264882168.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10759.52 Da
• Isoelectric Point: 10.3039

>T42771 WP_264882164.1 NZ_AP026873:524158-524442 [Enterobacter roggenkampii]
MTYELEFDPRALKEWSKLGDTVKNQFKKKLAGVLANPRVESARLHGLPDCYKIKLKASGYRLVYQVQDSVITVFFIAVGK
REKSAAYHDANKRL

Nucleotide

• Length: 285 bp

>T42771 NZ_AP026873:524158-524442 [Enterobacter roggenkampii]
ATGACTTATGAACTGGAATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGGATACGGTCAAAAACCAGTTTAA
GAAGAAACTTGCCGGGGTATTGGCAAATCCCCGGGTCGAATCGGCCCGCCTGCATGGGCTGCCGGATTGCTACAAAATCA
AACTCAAGGCGTCTGGCTATCGCCTGGTTTATCAGGTTCAGGACAGCGTTATAACGGTATTTTTTATCGCCGTTGGGAAA
AGAGAGAAATCAGCCGCTTATCACGACGCAAATAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT42771 WP_008501400.1 NZ_AP026873:523926-524168 [Enterobacter roggenkampii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT42771 NZ_AP026873:523926-524168 [Enterobacter roggenkampii]
ATGGCCACGCTAAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCGGTGCGATTGCTGTTTCAGTACGTTGCTGAAACGGGGCGCATGCCGGTGAAAACGGTCACCATCAGCGACA
GCGAAGATGCGCTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATAAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: V3EXX3