Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4635267..4636068 Replicon chromosome
Accession NZ_AP026794
Organism Escherichia coli strain IPCEC48

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag OPA53_RS22890 Protein ID WP_001094436.1
Coordinates 4635691..4636068 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag OPA53_RS22885 Protein ID WP_015953067.1
Coordinates 4635267..4635644 (+) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPA53_RS22850 (4631179) 4631179..4631859 + 681 WP_001282919.1 WYL domain-containing protein -
OPA53_RS22855 (4632007) 4632007..4632684 + 678 WP_001097301.1 hypothetical protein -
OPA53_RS22860 (4632690) 4632690..4632923 + 234 WP_001278287.1 DUF905 family protein -
OPA53_RS22865 (4633013) 4633013..4633831 + 819 WP_048266340.1 DUF932 domain-containing protein -
OPA53_RS22870 (4633922) 4633922..4634407 + 486 WP_264793731.1 antirestriction protein -
OPA53_RS22875 (4634422) 4634422..4634898 + 477 WP_001186756.1 RadC family protein -
OPA53_RS22880 (4634967) 4634967..4635188 + 222 WP_000692312.1 DUF987 domain-containing protein -
OPA53_RS22885 (4635267) 4635267..4635644 + 378 WP_015953067.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
OPA53_RS22890 (4635691) 4635691..4636068 + 378 WP_001094436.1 TA system toxin CbtA family protein Toxin
OPA53_RS22895 (4636065) 4636065..4636553 + 489 WP_000761714.1 DUF5983 family protein -
OPA53_RS22900 (4636565) 4636565..4636762 + 198 WP_000839254.1 DUF957 domain-containing protein -
OPA53_RS22905 (4636847) 4636847..4637557 + 711 WP_001621817.1 DUF4942 domain-containing protein -
OPA53_RS22910 (4637606) 4637606..4638361 - 756 WP_000065240.1 IS21-like element ISEc10 family helper ATPase IstB -
OPA53_RS22915 (4638358) 4638358..4639857 - 1500 WP_029700729.1 IS21-like element ISEc10 family transposase -
OPA53_RS22920 (4639948) 4639948..4640109 + 162 Protein_4508 DUF4942 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T42747 WP_001094436.1 NZ_AP026794:4635691-4636068 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

>T42747 NZ_AP026794:4635691-4636068 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT42747 WP_015953067.1 NZ_AP026794:4635267-4635644 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT42747 NZ_AP026794:4635267-4635644 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E2L1N0


Antitoxin

Source ID Structure
AlphaFold DB A0A5Z3CIS0

References