Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1980207..1981771 Replicon chromosome
Accession NZ_AP026403
Organism Aeromonas caviae strain KAM643

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCX50_RS09475 Protein ID WP_201964151.1
Coordinates 1980207..1981517 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCX50_RS09480 Protein ID WP_005329233.1
Coordinates 1981517..1981771 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX50_RS09460 (KAM643c_18280) 1975228..1976745 - 1518 WP_029314641.1 DUF1214 domain-containing protein -
OCX50_RS09465 (KAM643c_18290) 1977076..1979250 - 2175 WP_201964150.1 catalase/peroxidase HPI -
OCX50_RS09475 (KAM643c_18300) 1980207..1981517 - 1311 WP_201964151.1 type II toxin-antitoxin system HipA family toxin Toxin
OCX50_RS09480 (KAM643c_18310) 1981517..1981771 - 255 WP_005329233.1 helix-turn-helix domain-containing protein Antitoxin
OCX50_RS09485 (KAM643c_18320) 1982273..1982521 + 249 WP_010674978.1 hypothetical protein -
OCX50_RS09490 (KAM643c_18330) 1982942..1983193 - 252 WP_010674977.1 plasmid stabilization protein -
OCX50_RS09495 (KAM643c_18340) 1983272..1984579 - 1308 WP_021140687.1 Fic family protein -
OCX50_RS09500 (KAM643c_18360) 1984834..1985286 + 453 WP_021140686.1 DUF2384 domain-containing protein -
OCX50_RS09505 (KAM643c_18370) 1985618..1986196 + 579 WP_021140685.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49136.32 Da        Isoelectric Point: 7.1717

>T42479 WP_201964151.1 NZ_AP026403:c1981517-1980207 [Aeromonas caviae]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQILTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEITDSILGGLSSRAQRLKR

Download         Length: 1311 bp

>T42479 NZ_AP026403:c1981517-1980207 [Aeromonas caviae]
ATGGCCAGCCTGACGGTCTACATGAACGGATACCGGGTAGGTACCTTTACCAAGGCGACCAATGGTGCTCACCAATTTCA
GTACGATGAATCGTGGGTGAAGTTGCCAGGCAGCCGCCCCATCTCGCTCTCCATGCCATTACGCCAGCAGCGCTACCAGG
GCGATGAGGCCTATAACTTCTTCGATAATCTGCTGCCAGATAACCCGGAAGTAAGAAACCGGGTGGTGGCGCGCTATCAA
GCCGATTCCACCCAACCCTTTGATCTGCTCAGTTGCATTGGCCAGGACAGCGTGGGGGCATTGCAACTGGTGGCTCAGGG
CAGACCTGTGCCAGACGTTAAGCGCATTGAGTGCAAGCCGCTCTCTGACGCCGAACTGGAGCAGATCCTGACCAGCTACC
AGCAAGGGATCCCGCTTGGTATGGTGAGGGAAGAGGACGATTTTCGGATATCCATCGCCGGGGCTCAGGAAAAGACCGCG
TTACTCTACCTCGACAACCGTTGGTGCTTACCGCATGCAGCGACCCCAACCACCCACATTATCAAGCTGCCCATTGGCAA
GATCGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACCCTGATCGCCAAAGCAT
TGGGTCTTCCGGTTCCCCATTGCTTCATCATGCAGGTCGGCAAGGTCAAGGCTCTGGCGGTGGAACGCTTCGATCGGCGC
TACGCCACGGATCGCAGTTGGATCATGCGCCTGCCCCAAGAGGACTTCTGCCAGGTGTTGAATGTACCGTCAGCACGCAA
GTACGAGAGCCATGGTGGACCGGGCATTGCTGACATCATGACGACCCTGCTGGGATCGGCCACGCCGGAGCAGGATCGGT
ACCTGTTTATGAAGTCTCAGGTGTTGTTCTGGCTGCTGGCTGCCACTGATGGCCATGCCAAGAATTTCTCGGTGTTTATC
GAACCTGAAGGGCGTTTCCGGCTTACACCGTTTTACGACATCCTTTCCATGTATCCTGCATTTGGTGGTAAAGGATTACA
TCCCCGTGATGCCAAGTTGGCCATGGGGCTTACTGCAACCAAGGGCAAAAAATACGCGATAGAGCAGATATTTCCTCGCC
ATTTTTATCAAACGGCCAAGGCGATTGGTTTTGAACAAGTGCAGATGGAAAAAATCATCAGCGAGCTGACGGATAATCTG
GATGAGGTAATATCAATCGTTCGTCAGCAATTGCCTGATACATTTCCCACTGAGATTACAGATTCAATTTTGGGTGGACT
CAGTTCGAGAGCTCAACGCTTAAAACGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9271.66 Da        Isoelectric Point: 9.1571

>AT42479 WP_005329233.1 NZ_AP026403:c1981771-1981517 [Aeromonas caviae]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Download         Length: 255 bp

>AT42479 NZ_AP026403:c1981771-1981517 [Aeromonas caviae]
ATGAAAGTAACCAGCGCCAAGCAACTTAGTGCCTGTCTCAAGGATGCCAGGCTTTCGCAAAAGCTCTCCCAAGGCAAAGT
GGCCGGCAAGGTGGGGATCAGGCAGGACACGGTGTCCAGCTTCGAGCTCAATCCCGAGTCAACCAAGCTGGAGACCTTGT
TCAAGATCCTCGCCGCACTGGAACTCTCCCTCGATATCAGGCCCCGCACCGATCCTGCGGAAAACGCCACGCCTGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References