Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2126502..2126973 | Replicon | chromosome |
| Accession | NZ_AP026112 | ||
| Organism | Escherichia coli strain CEC03102 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO877_RS10590 | Protein ID | WP_001303511.1 |
| Coordinates | 2126695..2126973 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO877_RS10585 | Protein ID | WP_001302048.1 |
| Coordinates | 2126502..2126693 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO877_RS10545 (2121709) | 2121709..2122293 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| OO877_RS10550 (2122350) | 2122350..2122745 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO877_RS10555 (2122761) | 2122761..2123530 | - | 770 | Protein_2071 | DUF1627 domain-containing protein | - |
| OO877_RS10560 (2123556) | 2123556..2124296 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO877_RS10565 (2124303) | 2124303..2125265 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO877_RS10570 (2125288) | 2125288..2125713 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO877_RS10575 (2125710) | 2125710..2126012 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO877_RS10580 (2126110) | 2126110..2126481 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| OO877_RS10585 (2126502) | 2126502..2126693 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO877_RS10590 (2126695) | 2126695..2126973 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO877_RS10595 (2127325) | 2127325..2127624 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| OO877_RS10600 (2127696) | 2127696..2127914 | + | 219 | WP_001171930.1 | protein YdfC | - |
| OO877_RS10605 (2128483) | 2128483..2128671 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO877_RS10610 (2128668) | 2128668..2128859 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO877_RS10615 (2128952) | 2128952..2131423 | + | 2472 | WP_000048458.1 | exonuclease | - |
| OO877_RS10620 (2131496) | 2131496..2131747 | + | 252 | WP_000005552.1 | excisionase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 2037097..2134133 | 97036 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42324 WP_001303511.1 NZ_AP026112:2126695-2126973 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42324 NZ_AP026112:2126695-2126973 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42324 WP_001302048.1 NZ_AP026112:2126502-2126693 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42324 NZ_AP026112:2126502-2126693 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|