Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1171233..1171711 Replicon chromosome
Accession NZ_AP026112
Organism Escherichia coli strain CEC03102

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO877_RS05410 Protein ID WP_001303876.1
Coordinates 1171233..1171520 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO877_RS05415 Protein ID WP_000536233.1
Coordinates 1171520..1171711 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO877_RS05375 (1166382) 1166382..1168853 - 2472 WP_000034474.1 exonuclease -
OO877_RS05380 (1168947) 1168947..1169138 - 192 WP_001098307.1 DUF1482 family protein -
OO877_RS05385 (1169135) 1169135..1169323 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO877_RS05390 (1169897) 1169897..1170082 + 186 WP_001133046.1 hypothetical protein -
OO877_RS05395 (1170269) 1170269..1170658 - 390 WP_000394511.1 hypothetical protein -
OO877_RS05400 (1170670) 1170670..1170798 - 129 WP_000344963.1 protein YdfB -
OO877_RS05405 (1170800) 1170800..1170955 - 156 WP_000379575.1 DUF1391 family protein -
OO877_RS05410 (1171233) 1171233..1171520 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO877_RS05415 (1171520) 1171520..1171711 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO877_RS05420 (1171739) 1171739..1172140 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO877_RS05425 (1172249) 1172249..1172521 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO877_RS05430 (1172505) 1172505..1172930 + 426 WP_000693855.1 toxin YdaT family protein -
OO877_RS05435 (1173137) 1173137..1173592 - 456 WP_000273724.1 hypothetical protein -
OO877_RS05440 (1173671) 1173671..1174762 + 1092 WP_001205823.1 hypothetical protein -
OO877_RS05445 (1174769) 1174769..1175515 + 747 WP_000788745.1 ATP-binding protein -
OO877_RS05450 (1175537) 1175537..1176307 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42315 WP_001303876.1 NZ_AP026112:c1171520-1171233 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42315 NZ_AP026112:c1171520-1171233 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42315 WP_000536233.1 NZ_AP026112:c1171711-1171520 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42315 NZ_AP026112:c1171711-1171520 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References