41923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2113515..2113986 Replicon chromosome
Accession NZ_AP026087
Organism Escherichia coli strain 8_140198

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag OO841_RS10655 Protein ID WP_001303511.1
Coordinates 2113708..2113986 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag OO841_RS10650 Protein ID WP_001302048.1
Coordinates 2113515..2113706 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO841_RS10610 (2108722) 2108722..2109306 - 585 WP_000206793.1 DUF551 domain-containing protein -
OO841_RS10615 (2109363) 2109363..2109758 - 396 WP_001118159.1 DUF977 family protein -
OO841_RS10620 (2109774) 2109774..2110543 - 770 Protein_2080 DUF1627 domain-containing protein -
OO841_RS10625 (2110569) 2110569..2111309 - 741 WP_000788938.1 ATP-binding protein -
OO841_RS10630 (2111316) 2111316..2112278 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
OO841_RS10635 (2112301) 2112301..2112726 - 426 WP_000693943.1 toxin YdaT family protein -
OO841_RS10640 (2112723) 2112723..2113025 - 303 WP_000172738.1 transcriptional regulator -
OO841_RS10645 (2113123) 2113123..2113494 + 372 WP_001169686.1 hypothetical protein -
OO841_RS10650 (2113515) 2113515..2113706 + 192 WP_001302048.1 hypothetical protein Antitoxin
OO841_RS10655 (2113708) 2113708..2113986 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO841_RS10660 (2114339) 2114339..2114638 + 300 WP_001240334.1 hypothetical protein -
OO841_RS10665 (2114710) 2114710..2114928 + 219 WP_001171930.1 protein YdfC -
OO841_RS10670 (2115497) 2115497..2115685 + 189 WP_000449192.1 cell division inhibition protein DicB -
OO841_RS10675 (2115682) 2115682..2115873 + 192 WP_001090200.1 DUF1482 family protein -
OO841_RS10680 (2115966) 2115966..2117051 + 1086 Protein_2092 exonuclease -
OO841_RS10685 (2117102) 2117102..2118315 + 1214 WP_162829202.1 IS3-like element IS1203 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2031110..2122460 91350


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T41923 WP_001303511.1 NZ_AP026087:2113708-2113986 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T41923 NZ_AP026087:2113708-2113986 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT41923 WP_001302048.1 NZ_AP026087:2113515-2113706 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT41923 NZ_AP026087:2113515-2113706 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References