Detailed information of TA system TA041770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1065734..1066986
• Replicon: chromosome
• Accession: NZ_AP025937
• Organism: Streptococcus pneumoniae strain PZ900700792

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A4J2GTV6
• Locus tag: QML92_RS05245
• Protein ID: WP_000405373.1
• Coordinates: 1065734..1066510 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: QML92_RS05250
• Protein ID: WP_000579602.1
• Coordinates: 1066510..1066986 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QML92_RS05230 (PC0780_10370)	1060940..1061836	-	897	WP_000161642.1	restriction endonuclease	-
QML92_RS05235 (PC0780_10380)	1061861..1064884	-	3024	WP_001858282.1	DEAD/DEAH box helicase	-
QML92_RS05240 (PC0780_10390)	1064941..1065750	-	810	WP_000413878.1	SAVED domain-containing protein	-
QML92_RS05245 (PC0780_10400)	1065734..1066510	-	777	WP_000405373.1	type II toxin-antitoxin system toxin PezT	Toxin
QML92_RS05250 (PC0780_10410)	1066510..1066986	-	477	WP_000579602.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
QML92_RS05255 (PC0780_10420)	1067431..1067886	-	456	WP_000500478.1	hypothetical protein	-
QML92_RS05260 (PC0780_10440)	1068161..1069900	-	1740	Protein_1041	glycoside hydrolase family 13 protein	-
QML92_RS05265 (PC0780_10450)	1070063..1070947	-	885	WP_000710117.1	diacylglycerol kinase family lipid kinase	-
QML92_RS05270	1071059..1071913	-	855	Protein_1043	ADP-ribosylglycohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1060940..1082218	21278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29509.43 Da
• Isoelectric Point: 6.9224

>T41770 WP_000405373.1 NZ_AP025937:c1066510-1065734 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQSIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
ENGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNPARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAAEVLQEYLFGKWSKVEEEML
KVGEERMRDMSKSNGKDA

Nucleotide

• Length: 777 bp

>T41770 NZ_AP025937:c1066510-1065734 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAATCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAAAATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTATTAAAAAATA
AGGGGTATGAGGTACAATTAGCCTTAATTGCAACCAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTATGCTATCAATCCAAATCCAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGAAGTGCTACAAGAATACCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGTTG
AAGGTGGGAGAAGAACGGATGAGGGATATGAGTAAAAGTAATGGAAAAGATGCATAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18289.70 Da
• Isoelectric Point: 4.4188

>AT41770 WP_000579602.1 NZ_AP025937:c1066986-1066510 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT41770 NZ_AP025937:c1066986-1066510 [Streptococcus pneumoniae]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A4J2GTV6