Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4041999..4042656 Replicon chromosome
Accession NZ_AP025919
Organism Enterobacter hormaechei strain FUJ80378

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag NGK71_RS19450 Protein ID WP_017382887.1
Coordinates 4041999..4042409 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGK71_RS19455 Protein ID WP_003863437.1
Coordinates 4042390..4042656 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK71_RS19430 (FJMB80378_38170) 4037997..4039730 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
NGK71_RS19435 (FJMB80378_38180) 4039736..4040449 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGK71_RS19440 (FJMB80378_38190) 4040478..4041374 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGK71_RS19445 (FJMB80378_38200) 4041476..4041997 + 522 WP_032649423.1 flavodoxin FldB -
NGK71_RS19450 (FJMB80378_38210) 4041999..4042409 - 411 WP_017382887.1 protein YgfX Toxin
NGK71_RS19455 (FJMB80378_38220) 4042390..4042656 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGK71_RS19460 (FJMB80378_38230) 4042951..4043931 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGK71_RS19465 (FJMB80378_38240) 4044043..4044702 - 660 WP_003863433.1 hemolysin III family protein -
NGK71_RS19470 (FJMB80378_38250) 4044969..4045700 + 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
NGK71_RS19475 (FJMB80378_38260) 4045817..4047250 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41704 WP_017382887.1 NZ_AP025919:c4042409-4041999 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41704 NZ_AP025919:c4042409-4041999 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41704 WP_003863437.1 NZ_AP025919:c4042656-4042390 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41704 NZ_AP025919:c4042656-4042390 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References