Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2454281..2455020 Replicon chromosome
Accession NZ_AP025851
Organism Enterobacter hormaechei strain FUJ80068

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGJ26_RS11745 Protein ID WP_003857133.1
Coordinates 2454281..2454766 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ26_RS11750 Protein ID WP_003857131.1
Coordinates 2454754..2455020 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ26_RS11720 (FJMB80068_23020) 2449653..2450411 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NGJ26_RS11725 (FJMB80068_23030) 2450516..2451808 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGJ26_RS11730 (FJMB80068_23050) 2451808..2452422 + 615 WP_065420578.1 NUDIX hydrolase -
NGJ26_RS11735 (FJMB80068_23060) 2452680..2453645 + 966 WP_032648329.1 hypothetical protein -
NGJ26_RS11740 (FJMB80068_23070) 2453661..2454230 + 570 WP_032648331.1 hypothetical protein -
NGJ26_RS11745 (FJMB80068_23080) 2454281..2454766 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGJ26_RS11750 (FJMB80068_23090) 2454754..2455020 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ26_RS11755 (FJMB80068_23100) 2455084..2456013 - 930 WP_032648334.1 LysR family transcriptional regulator -
NGJ26_RS11760 (FJMB80068_23110) 2456143..2457525 + 1383 WP_032648336.1 MFS transporter -
NGJ26_RS11765 (FJMB80068_23120) 2457547..2458542 - 996 WP_017382342.1 DUF2891 domain-containing protein -
NGJ26_RS11770 (FJMB80068_23130) 2458552..2459538 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41372 WP_003857133.1 NZ_AP025851:c2454766-2454281 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41372 NZ_AP025851:c2454766-2454281 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41372 WP_003857131.1 NZ_AP025851:c2455020-2454754 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41372 NZ_AP025851:c2455020-2454754 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References