Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2497324..2498063 Replicon chromosome
Accession NZ_AP025847
Organism Enterobacter hormaechei strain FUJ80063

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGK57_RS12045 Protein ID WP_003857133.1
Coordinates 2497324..2497809 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK57_RS12050 Protein ID WP_003857131.1
Coordinates 2497797..2498063 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK57_RS12020 (FJMB80063_23640) 2492696..2493454 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NGK57_RS12025 (FJMB80063_23650) 2493559..2494851 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGK57_RS12030 (FJMB80063_23670) 2494851..2495465 + 615 WP_065420578.1 NUDIX hydrolase -
NGK57_RS12035 (FJMB80063_23680) 2495723..2496688 + 966 WP_032648329.1 hypothetical protein -
NGK57_RS12040 (FJMB80063_23690) 2496704..2497273 + 570 WP_032648331.1 hypothetical protein -
NGK57_RS12045 (FJMB80063_23700) 2497324..2497809 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGK57_RS12050 (FJMB80063_23710) 2497797..2498063 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK57_RS12055 (FJMB80063_23720) 2498127..2499056 - 930 WP_032648334.1 LysR family transcriptional regulator -
NGK57_RS12060 (FJMB80063_23730) 2499186..2500568 + 1383 WP_032648336.1 MFS transporter -
NGK57_RS12065 (FJMB80063_23740) 2500590..2501585 - 996 WP_017382342.1 DUF2891 domain-containing protein -
NGK57_RS12070 (FJMB80063_23750) 2501595..2502581 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41353 WP_003857133.1 NZ_AP025847:c2497809-2497324 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41353 NZ_AP025847:c2497809-2497324 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41353 WP_003857131.1 NZ_AP025847:c2498063-2497797 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41353 NZ_AP025847:c2498063-2497797 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References