Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 81879..82132 | Replicon | plasmid pla1 |
| Accession | NZ_AP025755 | ||
| Organism | Escherichia sp. KS167_9B strain KS-P079 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | QUE34_RS27095 | Protein ID | WP_001312851.1 |
| Coordinates | 81879..82028 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 82076..82132 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE34_RS27060 (77600) | 77600..78025 | + | 426 | Protein_92 | transposase | - |
| QUE34_RS27065 (78141) | 78141..78392 | + | 252 | WP_135276003.1 | hypothetical protein | - |
| QUE34_RS27070 (78839) | 78839..79156 | + | 318 | Protein_94 | transposase | - |
| QUE34_RS27075 (79290) | 79290..79476 | - | 187 | Protein_95 | hypothetical protein | - |
| QUE34_RS27080 (80179) | 80179..81036 | - | 858 | WP_000829162.1 | incFII family plasmid replication initiator RepA | - |
| QUE34_RS27085 (81029) | 81029..81103 | - | 75 | WP_001364037.1 | RepA leader peptide Tap | - |
| QUE34_RS27090 (81347) | 81347..81595 | - | 249 | WP_000083838.1 | replication regulatory protein RepA | - |
| QUE34_RS27095 (81879) | 81879..82028 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (82076) | 82076..82132 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82076) | 82076..82132 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82076) | 82076..82132 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82076) | 82076..82132 | + | 57 | NuclAT_1 | - | Antitoxin |
| QUE34_RS27100 (82284) | 82284..82748 | - | 465 | WP_000455478.1 | hypothetical protein | - |
| QUE34_RS27105 (82903) | 82903..83493 | - | 591 | WP_000766788.1 | DUF2726 domain-containing protein | - |
| QUE34_RS27110 (83531) | 83531..83740 | - | 210 | WP_001355319.1 | hemolysin expression modulator Hha | - |
| QUE34_RS27115 (84068) | 84068..84280 | - | 213 | WP_286338986.1 | hypothetical protein | - |
| QUE34_RS27120 (84415) | 84415..84975 | - | 561 | WP_000139355.1 | fertility inhibition protein FinO | - |
| QUE34_RS27125 (85030) | 85030..85767 | - | 738 | WP_000429592.1 | conjugal transfer pilus acetylase TraX | - |
| QUE34_RS27130 (85789) | 85789..86220 | - | 432 | WP_000447372.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | hlyD / hlyD / hlyD / hlyB / hlyB / hlyA / hlyC / estIa / faeJ / faeI / faeH / faeF / faeE / faeD / faeC / espP | 1..215429 | 215429 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T40859 WP_001312851.1 NZ_AP025755:c82028-81879 [Escherichia sp. KS167_9B]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T40859 NZ_AP025755:c82028-81879 [Escherichia sp. KS167_9B]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCTGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCTGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 57 bp
>AT40859 NZ_AP025755:82076-82132 [Escherichia sp. KS167_9B]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATCTCT
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATCTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
