Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 566191..566809 Replicon chromosome
Accession NZ_AP025754
Organism Escherichia sp. KS167_9B strain KS-P079

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QUE34_RS02770 Protein ID WP_001291435.1
Coordinates 566191..566409 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QUE34_RS02775 Protein ID WP_000344800.1
Coordinates 566435..566809 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE34_RS02735 (561481) 561481..562053 + 573 WP_032302581.1 YbaY family lipoprotein -
QUE34_RS02740 (562084) 562084..562395 - 312 WP_000409907.1 MGMT family protein -
QUE34_RS02750 (562773) 562773..563126 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QUE34_RS02755 (563168) 563168..564718 - 1551 WP_001353400.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QUE34_RS02760 (564882) 564882..565352 - 471 WP_000136192.1 YlaC family protein -
QUE34_RS02765 (565468) 565468..566019 - 552 WP_032302582.1 maltose O-acetyltransferase -
QUE34_RS02770 (566191) 566191..566409 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QUE34_RS02775 (566435) 566435..566809 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QUE34_RS02780 (567356) 567356..570505 - 3150 WP_001132494.1 efflux RND transporter permease AcrB -
QUE34_RS02785 (570528) 570528..571721 - 1194 WP_001353399.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T40827 WP_001291435.1 NZ_AP025754:c566409-566191 [Escherichia sp. KS167_9B]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T40827 NZ_AP025754:c566409-566191 [Escherichia sp. KS167_9B]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTGCGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT40827 WP_000344800.1 NZ_AP025754:c566809-566435 [Escherichia sp. KS167_9B]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT40827 NZ_AP025754:c566809-566435 [Escherichia sp. KS167_9B]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGATTGCCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAAAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References