Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 82536..82789 | Replicon | plasmid pla1 |
| Accession | NZ_AP025742 | ||
| Organism | Escherichia sp. 10290 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | QUE74_RS27805 | Protein ID | WP_001312851.1 |
| Coordinates | 82536..82685 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 82733..82789 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE74_RS27770 (78257) | 78257..78682 | + | 426 | Protein_93 | transposase | - |
| QUE74_RS27775 (78798) | 78798..79049 | + | 252 | WP_135276003.1 | hypothetical protein | - |
| QUE74_RS27780 (79496) | 79496..79813 | + | 318 | Protein_95 | transposase | - |
| QUE74_RS27785 (79947) | 79947..80133 | - | 187 | Protein_96 | hypothetical protein | - |
| QUE74_RS27790 (80836) | 80836..81693 | - | 858 | WP_000829162.1 | incFII family plasmid replication initiator RepA | - |
| QUE74_RS27795 (81686) | 81686..81760 | - | 75 | WP_001364037.1 | RepA leader peptide Tap | - |
| QUE74_RS27800 (82004) | 82004..82252 | - | 249 | WP_000083838.1 | replication regulatory protein RepA | - |
| QUE74_RS27805 (82536) | 82536..82685 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (82733) | 82733..82789 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82733) | 82733..82789 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82733) | 82733..82789 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82733) | 82733..82789 | + | 57 | NuclAT_1 | - | Antitoxin |
| QUE74_RS27810 (82941) | 82941..83405 | - | 465 | WP_000455478.1 | hypothetical protein | - |
| QUE74_RS27815 (83560) | 83560..84150 | - | 591 | WP_000766788.1 | DUF2726 domain-containing protein | - |
| QUE74_RS27820 (84188) | 84188..84397 | - | 210 | WP_001355319.1 | hemolysin expression modulator Hha | - |
| QUE74_RS27825 (84725) | 84725..84937 | - | 213 | WP_001364091.1 | hypothetical protein | - |
| QUE74_RS27830 (85072) | 85072..85632 | - | 561 | WP_000139355.1 | fertility inhibition protein FinO | - |
| QUE74_RS27835 (85687) | 85687..86424 | - | 738 | WP_000429592.1 | conjugal transfer pilus acetylase TraX | - |
| QUE74_RS27840 (86446) | 86446..86877 | - | 432 | WP_000447372.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | hlyD / hlyD / hlyD / hlyB / hlyB / hlyA / hlyA / hlyC / estIa / faeJ / faeI / faeH / faeF / faeE / faeD / faeC / espP | 1..224339 | 224339 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T40729 WP_001312851.1 NZ_AP025742:c82685-82536 [Escherichia sp. 10290]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T40729 NZ_AP025742:c82685-82536 [Escherichia sp. 10290]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCTGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCTGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 57 bp
>AT40729 NZ_AP025742:82733-82789 [Escherichia sp. 10290]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATCTCT
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATCTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
