Detailed information of TA system TA040315

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1852373..1852886
• Replicon: chromosome
• Accession: NZ_AP025477
• Organism: Vibrio crassostreae strain LMG 22240

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OC193_RS23905
• Protein ID: WP_017069754.1
• Coordinates: 1852373..1852639 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A4R2ER32
• Locus tag: OC193_RS23910
• Protein ID: WP_017069755.1
• Coordinates: 1852629..1852886 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OC193_RS23885	1848152..1849159	-	1008	WP_048663837.1	LacI family DNA-binding transcriptional regulator	-
OC193_RS23890	1849373..1850443	+	1071	WP_048663836.1	cellulase family glycosylhydrolase	-
OC193_RS23895	1850514..1851902	+	1389	WP_123283731.1	MFS transporter	-
OC193_RS23900	1852030..1852341	-	312	WP_048663834.1	DUF4144 domain-containing protein	-
OC193_RS23905	1852373..1852639	-	267	WP_017069754.1	Txe/YoeB family addiction module toxin	Toxin
OC193_RS23910	1852629..1852886	-	258	WP_017069755.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OC193_RS23915	1853073..1853864	-	792	WP_048663833.1	hypothetical protein	-
OC193_RS23920	1854001..1854702	-	702	WP_048663832.1	flavin reductase	-
OC193_RS23925	1854938..1856269	+	1332	WP_048663831.1	ferric reductase-like transmembrane domain-containing protein	-
OC193_RS23930	1856489..1856896	+	408	WP_017054885.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10524.97 Da
• Isoelectric Point: 9.3651

>T40315 WP_017069754.1 NZ_AP025477:c1852639-1852373 [Vibrio crassostreae]
MTNDRKIVFTDNAWEDYLYWQTQDKKTLKKLNKLIEAAKRTPFEGIGKPEPLVGNLSGFWSRRIDDKNRLVYKADDDNFY
IIACRHHY

Nucleotide

• Length: 267 bp

>T40315 NZ_AP025477:c1852639-1852373 [Vibrio crassostreae]
ATGACGAATGATCGAAAGATTGTATTTACAGATAATGCTTGGGAAGATTACCTATACTGGCAAACCCAAGACAAGAAAAC
GCTCAAGAAACTAAACAAGTTGATTGAAGCTGCCAAAAGAACGCCCTTTGAAGGGATTGGAAAGCCGGAGCCACTAGTCG
GCAACCTGTCTGGCTTTTGGTCAAGACGAATCGATGACAAGAATCGATTAGTGTACAAAGCAGATGACGATAACTTTTAC
ATAATTGCTTGTCGTCACCACTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9564.58 Da
• Isoelectric Point: 4.1353

>AT40315 WP_017069755.1 NZ_AP025477:c1852886-1852629 [Vibrio crassostreae]
MNIVSFTEARNSLKSVLDRVVDDSDVTVITRRDSEDAVVMSLDHFNSMQETLYLMSSPKNAERLAESIAQLETGNTTVRE
LNNDE

Nucleotide

• Length: 258 bp

>AT40315 NZ_AP025477:c1852886-1852629 [Vibrio crassostreae]
ATGAATATTGTTTCTTTTACTGAGGCCAGAAATAGCCTTAAGTCTGTGCTCGATAGAGTAGTAGACGATTCTGATGTTAC
GGTAATAACCAGACGAGATTCAGAAGATGCCGTGGTAATGTCTCTTGATCATTTTAATTCAATGCAAGAAACCTTGTACC
TAATGAGCTCGCCTAAAAACGCTGAAAGATTGGCTGAATCCATTGCTCAACTCGAAACCGGAAATACAACCGTTCGAGAA
TTGAATAATGACGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4R2ER32