Detailed information of TA system TA040307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1293738..1294371
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1E5D3W9
• Locus tag: OCV39_RS06035
• Protein ID: WP_023603298.1
• Coordinates: 1293738..1294070 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OCV39_RS06040
• Protein ID: WP_012550279.1
• Coordinates: 1294057..1294371 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS06010	1289648..1290145	-	498	WP_261889266.1	GNAT family N-acetyltransferase	-
OCV39_RS06015	1290142..1290414	-	273	WP_261889267.1	DUF1778 domain-containing protein	-
OCV39_RS06020	1291109..1291906	+	798	WP_261889268.1	hypothetical protein	-
OCV39_RS06025	1292043..1292489	+	447	WP_171757633.1	hypothetical protein	-
OCV39_RS06030	1292639..1293532	+	894	WP_261889269.1	hypothetical protein	-
OCV39_RS06035	1293738..1294070	+	333	WP_023603298.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV39_RS06040	1294057..1294371	+	315	WP_012550279.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
OCV39_RS06045	1294506..1295009	+	504	WP_261889270.1	hypothetical protein	-
OCV39_RS06050	1295156..1295659	+	504	WP_261889271.1	peptide deformylase	-
OCV39_RS06055	1295810..1296466	+	657	WP_261889272.1	hypothetical protein	-
OCV39_RS06060	1296704..1297183	+	480	WP_261889273.1	DM13 domain-containing protein	-
OCV39_RS06065	1297906..1298352	+	447	WP_261889274.1	GNAT family N-acetyltransferase	-
OCV39_RS06070	1298458..1298895	+	438	WP_261889275.1	GNAT family N-acetyltransferase	-
OCV39_RS06075	1298913..1299002	+	90	WP_071881309.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-92)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12934.81 Da
• Isoelectric Point: 10.0960

>T40307 WP_023603298.1 NZ_AP025472:1293738-1294070 [Vibrio cortegadensis]
MKSIFVESTIFEKYRNEYLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS

Nucleotide

• Length: 333 bp

>T40307 NZ_AP025472:1293738-1294070 [Vibrio cortegadensis]
ATGAAAAGTATATTTGTCGAATCGACCATATTTGAAAAGTACCGTAATGAGTATCTCAGCGATGAAGAGTTTAGACTTTT
TCAAGCTGAATTAATGTCTAACCCGAAACAGGGTGATGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGCAAGGGCAAGCGTGGTGGCTCTCGTGTTATCTATTACTTCCTCGATGAAAAACGTCGTTTCTACTTGCTGACA
ATTTATGGCAAGAATGAAATGTCCGATTTAACCGCAGACCAAAAGAAACAATTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAATCGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11763.20 Da
• Isoelectric Point: 6.2155

>AT40307 WP_012550279.1 NZ_AP025472:1294057-1294371 [Vibrio cortegadensis]
MSNRDLFTELSSAIIEAKEHSEGKLTLKTHQVNDFSELDISPNEIVSIREQFNMSRGVFAHLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Nucleotide

• Length: 315 bp

>AT40307 NZ_AP025472:1294057-1294371 [Vibrio cortegadensis]
ATGAGCAATCGTGACCTATTTACAGAGTTAAGTTCAGCTATTATTGAGGCTAAAGAACATTCTGAGGGTAAGTTAACCCT
TAAAACTCATCAAGTTAACGATTTCAGTGAGTTAGATATTTCACCTAATGAAATCGTGAGTATTCGTGAACAATTTAATA
TGTCTCGTGGTGTGTTTGCACATTTACTGCATACATCATCTCGTACATTAGAAAATTGGGAACAAGGGCGTAGCGCACCA
AATGGACAAGCGGTAACCCTTTTAAAATTGGTTCAGCGTCATCCAGAAACCCTGTCACATATCGCTGAGCTATAA

Structures

Toxin

• AlphaFold DB: A0A1E5D3W9