Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1771642..1772281 Replicon chromosome
Accession NZ_AP025281
Organism Aliamphritea hakodatensis strain PT3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PCI15_RS08145 Protein ID WP_271273836.1
Coordinates 1772105..1772281 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PCI15_RS08140 Protein ID WP_271273835.1
Coordinates 1771642..1772052 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCI15_RS08120 1767708..1768481 + 774 WP_271273831.1 hypothetical protein -
PCI15_RS08125 1768491..1770167 + 1677 WP_271273832.1 hypothetical protein -
PCI15_RS08130 1770167..1771285 + 1119 WP_271273833.1 hypothetical protein -
PCI15_RS08135 1771285..1771611 + 327 WP_271273834.1 hypothetical protein -
PCI15_RS08140 1771642..1772052 - 411 WP_271273835.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PCI15_RS08145 1772105..1772281 - 177 WP_271273836.1 type II toxin-antitoxin system HicA family toxin Toxin
PCI15_RS08150 1772625..1773503 - 879 WP_271273837.1 hypothetical protein -
PCI15_RS08155 1773840..1774640 - 801 WP_271273838.1 hypothetical protein -
PCI15_RS08160 1774728..1774895 - 168 WP_271273839.1 hypothetical protein -
PCI15_RS08165 1775738..1775986 - 249 WP_271273840.1 GlsB/YeaQ/YmgE family stress response membrane protein -
PCI15_RS08170 1776190..1776522 - 333 WP_271273841.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-128)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6761.86 Da        Isoelectric Point: 10.8173

>T40237 WP_271273836.1 NZ_AP025281:c1772281-1772105 [Aliamphritea hakodatensis]
VKQSEFRRWLESQGVEIKQGTKHLKLYFNGKQSTMPRHPGKEIGEGLRKAIIKQLELN

Download         Length: 177 bp

>T40237 NZ_AP025281:c1772281-1772105 [Aliamphritea hakodatensis]
GTGAAGCAAAGCGAGTTTCGGAGGTGGCTGGAAAGCCAAGGAGTAGAGATAAAACAGGGAACCAAACACCTGAAACTCTA
TTTCAACGGCAAGCAAAGCACCATGCCACGACACCCCGGAAAAGAAATAGGCGAAGGTTTAAGAAAAGCAATCATCAAAC
AGCTTGAATTAAACTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15341.37 Da        Isoelectric Point: 4.5527

>AT40237 WP_271273835.1 NZ_AP025281:c1772052-1771642 [Aliamphritea hakodatensis]
MRYSAIIEKDGSGFIAKFPDIPEALAGGETYEETIQEAQDALITAFEFYFEDQRPVPEPSKTNTGEPIEVPLSVWTKVLL
LNTMLEQGVSQSELARRMGTRRQEIQRIVDLHHTTKIDTLSQALQALDKRFSISIS

Download         Length: 411 bp

>AT40237 NZ_AP025281:c1772052-1771642 [Aliamphritea hakodatensis]
ATGAGATATTCAGCAATCATCGAAAAAGACGGAAGCGGCTTTATTGCCAAATTTCCAGACATTCCCGAAGCCCTGGCAGG
CGGCGAAACTTACGAAGAAACCATACAGGAAGCACAGGACGCCCTGATAACCGCCTTCGAATTTTACTTTGAAGACCAGC
GCCCAGTTCCTGAACCTTCTAAAACCAACACAGGGGAACCTATTGAAGTCCCCTTAAGTGTGTGGACAAAAGTTTTACTC
CTGAACACCATGCTAGAACAAGGCGTCAGCCAGAGCGAGCTGGCGCGACGAATGGGAACCCGCCGCCAGGAGATTCAACG
AATTGTCGACCTCCACCACACAACCAAGATTGACACACTGAGCCAGGCACTGCAGGCACTCGATAAGAGATTCAGCATTT
CTATATCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References