Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1567050..1567718 Replicon chromosome
Accession NZ_AP025257
Organism Paraburkholderia terrae strain KU-15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PTKU15_RS24015 Protein ID WP_091776683.1
Coordinates 1567050..1567391 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTKU15_RS24020 Protein ID WP_086914644.1
Coordinates 1567407..1567718 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTKU15_RS23995 (PTKU15_47350) 1562599..1563576 + 978 WP_229514800.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -
PTKU15_RS24000 (PTKU15_47360) 1563671..1564675 + 1005 WP_042316651.1 alpha-ketoacid dehydrogenase subunit beta -
PTKU15_RS24005 (PTKU15_47370) 1564691..1565803 + 1113 WP_229514799.1 acetoin dehydrogenase dihydrolipoyllysine-residue acetyltransferase subunit -
PTKU15_RS24010 (PTKU15_47380) 1565806..1566780 + 975 WP_229514798.1 lipoyl synthase -
PTKU15_RS24015 (PTKU15_47390) 1567050..1567391 + 342 WP_091776683.1 toxin Toxin
PTKU15_RS24020 (PTKU15_47400) 1567407..1567718 + 312 WP_086914644.1 helix-turn-helix domain-containing protein Antitoxin
PTKU15_RS24025 (PTKU15_47410) 1567813..1569279 - 1467 WP_042316640.1 NAD-dependent succinate-semialdehyde dehydrogenase -
PTKU15_RS24030 (PTKU15_47420) 1570083..1571366 - 1284 WP_042306565.1 4-aminobutyrate--2-oxoglutarate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13205.25 Da        Isoelectric Point: 9.3431

>T40198 WP_091776683.1 NZ_AP025257:1567050-1567391 [Paraburkholderia terrae]
MAATFVELAPFRRCREDYLMDDEYRALQIVLMQNPEAGDVVRGTGGLRKLRFGDARRGKGKRGGLRVMYYYWVKGPQFWM
FTLYDKDEAEDLSSKERGVLSEMLREVIKLADR

Download         Length: 342 bp

>T40198 NZ_AP025257:1567050-1567391 [Paraburkholderia terrae]
ATGGCGGCGACTTTCGTCGAACTGGCGCCTTTTCGACGGTGCCGGGAAGACTATTTGATGGACGACGAATATCGCGCACT
CCAGATTGTGCTGATGCAGAACCCGGAAGCGGGAGATGTCGTCAGGGGAACGGGCGGTCTGCGCAAACTCCGTTTCGGCG
ACGCACGTCGTGGGAAGGGAAAGCGCGGCGGGCTCAGGGTGATGTATTACTACTGGGTGAAAGGCCCGCAGTTCTGGATG
TTCACGCTATACGACAAGGACGAAGCGGAAGATTTATCGTCGAAGGAGCGAGGGGTTCTCTCCGAGATGCTGAGAGAAGT
CATCAAGCTTGCGGATCGATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11833.61 Da        Isoelectric Point: 9.7238

>AT40198 WP_086914644.1 NZ_AP025257:1567407-1567718 [Paraburkholderia terrae]
MKRNLFAELTEGLDELKSAHEGKTTLHKVKVEIRDKLEVTADEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIKLVEKHPETIQMLETL

Download         Length: 312 bp

>AT40198 NZ_AP025257:1567407-1567718 [Paraburkholderia terrae]
ATGAAACGGAATCTGTTTGCCGAATTGACGGAAGGGCTCGATGAACTCAAGTCCGCTCACGAAGGCAAGACAACACTTCA
CAAGGTCAAGGTTGAGATTCGTGACAAGCTGGAAGTGACGGCTGACGAGATCCGGGCCGTACGCGAATCCATCAACGCGT
CGCAGGCGGTCATGGCGCGTCGTCTGCGCGTGAACGAGCGGACCTATCAGAATTGGGAGCAAGGGCGGGCGAAGCCGAAC
GCCCAGGCTGCTGTGCTGATCAAGCTGGTTGAAAAGCATCCTGAGACGATACAGATGCTCGAAACCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References