Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2458619..2459597 Replicon chromosome
Accession NZ_AP025245
Organism Acidianus sp. HS-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HS5_RS13670 Protein ID WP_236751912.1
Coordinates 2458619..2459236 (-) Length 206 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HS5_RS13675 Protein ID WP_236751913.1
Coordinates 2459229..2459597 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS5_RS13650 (HS5_27120) 2454874..2455221 + 348 WP_236751908.1 hypothetical protein -
HS5_RS13655 (HS5_27130) 2455640..2455996 - 357 WP_236751909.1 hypothetical protein -
HS5_RS13660 (HS5_27140) 2456717..2458099 + 1383 WP_236751910.1 MFS transporter -
HS5_RS13665 (HS5_27150) 2458192..2458638 + 447 WP_236751911.1 cation-binding protein -
HS5_RS13670 (HS5_27160) 2458619..2459236 - 618 WP_236751912.1 helix-turn-helix domain-containing protein Toxin
HS5_RS13675 (HS5_27170) 2459229..2459597 - 369 WP_236751913.1 DUF488 domain-containing protein Antitoxin
HS5_RS13680 2459610..2459774 + 165 WP_236751914.1 hypothetical protein -
HS5_RS13685 (HS5_27180) 2459904..2460074 - 171 WP_236751915.1 hypothetical protein -
HS5_RS13690 (HS5_27190) 2460308..2460637 - 330 WP_236751916.1 hypothetical protein -
HS5_RS13695 (HS5_27200) 2461310..2462032 + 723 WP_236751917.1 GNAT family N-acetyltransferase -
HS5_RS13700 (HS5_27210) 2462044..2462205 - 162 WP_236751918.1 type II toxin-antitoxin system VapC family toxin -
HS5_RS13705 (HS5_27220) 2462361..2462621 - 261 WP_236751919.1 ribbon-helix-helix domain-containing protein -
HS5_RS13710 (HS5_27230) 2463099..2463443 + 345 WP_236751920.1 hypothetical protein -
HS5_RS13715 (HS5_27240) 2463526..2463921 + 396 WP_236751921.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 206 a.a.        Molecular weight: 23328.13 Da        Isoelectric Point: 8.6439

>T40176 WP_236751912.1 NZ_AP025245:c2459236-2458619 [Acidianus sp. HS-5]
MHKTPFEVTVLVEDHPCEVMRIISSSGLKASVENVKLGEQITDHIVQFEKEVDKNDVQKLKGNAVKVLRLSNNKVWVRTN
GCTVCKILYTSDVVVEKIRVVKERTLIYTLLVPNNSSLKEFLSSLIQNDVKVTVIDVSEISDTALTERQIEILKLAYKLG
YFDDDRKISLSQLAEKLGISAPTLDEILRRALRKVVKYYLNKHES

Download         Length: 618 bp

>T40176 NZ_AP025245:c2459236-2458619 [Acidianus sp. HS-5]
ATGCATAAGACTCCATTTGAGGTTACTGTTTTAGTAGAGGATCATCCTTGTGAAGTAATGCGGATTATATCCTCAAGCGG
ATTAAAGGCGAGCGTAGAGAACGTAAAATTGGGAGAGCAGATCACTGATCATATAGTACAATTTGAGAAGGAAGTGGATA
AGAATGATGTGCAAAAACTTAAGGGAAACGCAGTCAAGGTTTTGAGGTTATCTAACAATAAAGTTTGGGTTAGAACTAAC
GGCTGTACAGTTTGTAAAATCCTTTATACTTCAGACGTTGTAGTTGAAAAAATTAGAGTAGTTAAGGAGAGGACTCTTAT
ATACACTTTACTTGTACCTAATAATTCATCACTCAAGGAATTTCTCTCTAGCCTTATACAGAATGACGTAAAGGTAACTG
TAATTGACGTCTCTGAAATTTCAGATACGGCGTTAACTGAAAGGCAAATTGAAATACTTAAACTGGCATACAAATTAGGT
TACTTTGACGACGATAGAAAAATTTCATTAAGCCAATTGGCGGAAAAACTAGGAATTTCTGCTCCAACCTTAGATGAGAT
CTTACGTAGGGCGTTAAGAAAAGTTGTAAAATATTATCTTAATAAGCATGAAAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14652.83 Da        Isoelectric Point: 9.7196

>AT40176 WP_236751913.1 NZ_AP025245:c2459597-2459229 [Acidianus sp. HS-5]
MIKVKRVYEPIEKDDGVRILVDRLWPRGIKKEKVDVWLRDIAPSDELRVWFNHDSSKWEEFKRRYFDELDKNPKVEVLLQ
IIKKGNNVTLLYSAKSPYNNAVALKEYLENKLKSERQEYNNA

Download         Length: 369 bp

>AT40176 NZ_AP025245:c2459597-2459229 [Acidianus sp. HS-5]
ATGATAAAGGTAAAAAGAGTTTATGAACCTATAGAGAAGGATGACGGAGTTAGGATATTAGTAGATAGGCTTTGGCCTAG
AGGCATTAAAAAGGAAAAGGTAGATGTTTGGCTTAGGGACATAGCACCTAGTGACGAGTTAAGGGTGTGGTTTAATCATG
ATTCTTCAAAGTGGGAGGAATTTAAGAGGAGGTATTTTGACGAATTGGATAAAAACCCTAAAGTTGAGGTATTATTACAA
ATTATTAAGAAAGGTAATAACGTTACTTTACTTTATTCTGCCAAATCTCCTTATAATAATGCAGTAGCGTTGAAAGAATA
CCTAGAGAATAAATTAAAAAGTGAGAGGCAAGAGTATAATAATGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References