Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1482501..1483101 Replicon chromosome
Accession NZ_AP025245
Organism Acidianus sp. HS-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HS5_RS07980 Protein ID WP_236753500.1
Coordinates 1482501..1482857 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HS5_RS07985 Protein ID WP_236750784.1
Coordinates 1482880..1483101 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS5_RS14515 1478787..1478912 - 126 WP_256445533.1 hypothetical protein -
HS5_RS07970 (HS5_16130) 1479191..1481068 - 1878 WP_236750780.1 DUF2075 domain-containing protein -
HS5_RS07975 (HS5_16140) 1481544..1482107 + 564 WP_236750782.1 hypothetical protein -
HS5_RS07980 (HS5_16150) 1482501..1482857 - 357 WP_236753500.1 type II toxin-antitoxin system VapC family toxin Toxin
HS5_RS07985 (HS5_16160) 1482880..1483101 - 222 WP_236750784.1 hypothetical protein Antitoxin
HS5_RS07990 (HS5_16170) 1483469..1483843 - 375 WP_236750786.1 type II toxin-antitoxin system VapC family toxin -
HS5_RS07995 (HS5_16180) 1483809..1484063 - 255 WP_236750788.1 antitoxin VapB family protein -
HS5_RS08000 (HS5_16190) 1484267..1485073 + 807 WP_236750790.1 amidohydrolase family protein -
HS5_RS08005 (HS5_16200) 1485576..1486427 + 852 WP_236750792.1 apolipoprotein A1/A4/E family protein -
HS5_RS08010 (HS5_16210) 1486690..1486923 + 234 WP_236750794.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HS5_RS08015 (HS5_16220) 1486908..1487339 + 432 WP_236750796.1 PIN domain-containing protein -
HS5_RS08020 (HS5_16230) 1487381..1487872 - 492 WP_236750798.1 PaREP1 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(4-109)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13626.03 Da        Isoelectric Point: 7.2019

>T40174 WP_236753500.1 NZ_AP025245:c1482857-1482501 [Acidianus sp. HS-5]
ITKEPGWEKLEKLLREGETLDLALIETSIWRKSSLLGIMKHEDSIVALKAVKDILPQLLIIHKSTNFLQRAMEVSINEKI
PIYDSLYIALAEDRKEKLVTADKKQYEVALKYVKAELY

Download         Length: 357 bp

>T40174 NZ_AP025245:c1482857-1482501 [Acidianus sp. HS-5]
ATTACTAAGGAACCGGGATGGGAAAAGTTAGAGAAATTATTAAGGGAAGGAGAAACATTAGATCTTGCACTTATTGAAAC
TTCCATATGGAGGAAGTCGTCATTATTAGGTATAATGAAACATGAAGATTCAATAGTAGCTTTAAAAGCAGTTAAAGACA
TCTTACCCCAATTATTAATAATTCATAAAAGTACCAATTTTTTACAGAGAGCTATGGAGGTTTCAATTAACGAAAAAATA
CCAATCTATGATTCACTTTATATAGCGTTAGCAGAGGACAGGAAAGAGAAGCTTGTAACCGCAGACAAGAAGCAGTACGA
GGTAGCTTTAAAATACGTTAAAGCCGAGCTTTACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8908.17 Da        Isoelectric Point: 4.6748

>AT40174 WP_236750784.1 NZ_AP025245:c1483101-1482880 [Acidianus sp. HS-5]
MKTVYSLRIDKELREEMEKYDIKWNEEIEEFIRKRIEELKKEEAMRKLHEIISSLPETEPIGAKLVTEDRDNN

Download         Length: 222 bp

>AT40174 NZ_AP025245:c1483101-1482880 [Acidianus sp. HS-5]
ATGAAGACCGTATACAGTTTAAGAATAGACAAGGAATTGAGAGAGGAGATGGAAAAGTACGACATAAAGTGGAACGAGGA
AATAGAGGAGTTTATAAGAAAGAGAATCGAGGAGCTAAAAAAGGAAGAGGCTATGAGGAAATTGCACGAGATAATCTCAT
CATTACCTGAAACCGAACCGATAGGTGCGAAATTGGTGACGGAAGATAGGGATAATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References