Detailed information of TA system TA040173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 338718..339315
• Replicon: chromosome
• Accession: NZ_AP025245
• Organism: Acidianus sp. HS-5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HS5_RS01870
• Protein ID: WP_236753617.1
• Coordinates: 338718..339101 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HS5_RS01875
• Protein ID: WP_236752384.1
• Coordinates: 339091..339315 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HS5_RS01860	336331..336534	+	204	WP_236752382.1	hypothetical protein	-
HS5_RS01865 (HS5_03710)	336693..337841	+	1149	WP_236752383.1	hypothetical protein	-
HS5_RS01870	338718..339101	-	384	WP_236753617.1	type II toxin-antitoxin system VapC family toxin	Toxin
HS5_RS01875 (HS5_03730)	339091..339315	-	225	WP_236752384.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HS5_RS01880 (HS5_03740)	339676..340137	+	462	WP_236752385.1	hypothetical protein	-
HS5_RS01885 (HS5_03750)	340294..341661	+	1368	WP_236752386.1	APC family permease	-
HS5_RS01890 (HS5_03770)	342524..343249	+	726	WP_236752387.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (7-123)

Antitoxin

• Post-segregation antitoxin CcdA (6-46)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14542.86 Da
• Isoelectric Point: 7.0081

>T40173 WP_236753617.1 NZ_AP025245:c339101-338718 [Acidianus sp. HS-5]
IRGKFLLDASSIYPLLNYVDSIDVSEVYILPLTFYEVGNAVWKESYIHRRVKDPFTLSSLFQKFMEKLKVLSNPPANEVM
KVAVNMGLTFYDASYVYSAKVNNLTLVSEDKDLIKKANAISFKDFIE

Nucleotide

• Length: 384 bp

>T40173 NZ_AP025245:c339101-338718 [Acidianus sp. HS-5]
ATAAGAGGTAAGTTTCTTTTAGACGCCTCATCAATATATCCCCTCTTAAATTACGTTGATAGTATCGACGTAAGTGAGGT
TTACATACTTCCCCTTACCTTTTATGAAGTAGGTAACGCAGTATGGAAAGAGTCTTACATTCACAGAAGGGTTAAAGACC
CCTTTACTCTTTCTTCGCTATTTCAAAAGTTTATGGAGAAGTTGAAGGTGTTAAGTAACCCTCCAGCTAATGAGGTAATG
AAGGTGGCTGTAAATATGGGGCTGACTTTTTACGACGCGTCTTACGTATATTCTGCTAAAGTTAATAACCTTACCTTGGT
GTCAGAGGATAAGGATCTAATAAAGAAAGCTAATGCCATTTCTTTTAAGGACTTTATTGAATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8825.25 Da
• Isoelectric Point: 4.8700

>AT40173 WP_236752384.1 NZ_AP025245:c339315-339091 [Acidianus sp. HS-5]
MSTVLSVRVRKELKEKAEQLGIDIREVVEKALEEAIKEKEKEEIKELAMKIKELMKDVSEEEWVEAIREERNKR

Nucleotide

• Length: 225 bp

>AT40173 NZ_AP025245:c339315-339091 [Acidianus sp. HS-5]
ATGTCAACAGTATTGAGCGTAAGGGTCAGGAAGGAACTTAAGGAAAAGGCTGAGCAATTAGGAATAGACATTAGGGAAGT
GGTTGAGAAGGCACTTGAAGAAGCAATTAAGGAGAAGGAAAAGGAGGAGATCAAGGAACTTGCAATGAAAATTAAGGAAT
TAATGAAGGACGTAAGTGAAGAAGAGTGGGTTGAAGCGATAAGGGAAGAGAGGAATAAGAGGTAA