Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1394445..1395091 Replicon chromosome
Accession NZ_AP025226
Organism Saccharolobus caldissimus strain JCM 32116

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SACC_RS07805 Protein ID WP_229572377.1
Coordinates 1394445..1394834 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SACC_RS07810 Protein ID WP_187146859.1
Coordinates 1394831..1395091 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SACC_RS07760 (SACC_15320) 1389762..1390214 + 453 WP_229572372.1 alanyl-tRNA editing protein -
SACC_RS07765 1390491..1390667 - 177 WP_229572373.1 hypothetical protein -
SACC_RS07770 (SACC_15330) 1390928..1391476 + 549 WP_229572374.1 class I SAM-dependent methyltransferase -
SACC_RS07775 (SACC_15340) 1391923..1392342 - 420 WP_229572578.1 ATP-binding protein -
SACC_RS07780 (SACC_15350) 1392370..1392858 - 489 WP_229572579.1 AAA family ATPase -
SACC_RS07785 (SACC_15360) 1392996..1393139 + 144 Protein_1518 transposase -
SACC_RS07790 (SACC_15370) 1393108..1393455 - 348 WP_229572375.1 AAA family ATPase -
SACC_RS07795 1393509..1393697 + 189 WP_229572376.1 hypothetical protein -
SACC_RS07800 1393694..1393774 - 81 Protein_1521 type II toxin-antitoxin system RelE/ParE family toxin -
SACC_RS07805 (SACC_15380) 1394445..1394834 - 390 WP_229572377.1 type II toxin-antitoxin system VapC family toxin Toxin
SACC_RS07810 (SACC_15390) 1394831..1395091 - 261 WP_187146859.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SACC_RS07815 (SACC_15400) 1395479..1395715 + 237 WP_229572378.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SACC_RS07820 (SACC_15410) 1395693..1396091 + 399 WP_229572379.1 type II toxin-antitoxin system VapC family toxin -
SACC_RS07825 (SACC_15420) 1397015..1398010 + 996 WP_229572380.1 hypothetical protein -
SACC_RS07830 (SACC_15430) 1399059..1399232 - 174 WP_229572381.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1391923..1400629 8706
- flank IS/Tn - - 1392954..1393139 185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

SpoVT-AbrB domain

(4-46)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15281.02 Da        Isoelectric Point: 5.2883

>T40168 WP_229572377.1 NZ_AP025226:c1394834-1394445 [Saccharolobus caldissimus]
MIFLDANFLIYLNLGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVRYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVRPSDAFHIAVMLNNSINVILSEDKELDKVVEIKRIWIK

Download         Length: 390 bp

>T40168 NZ_AP025226:c1394834-1394445 [Saccharolobus caldissimus]
TTGATTTTTCTTGATGCTAATTTCTTAATCTACTTAAACCTGGGTGTAAGTGAGGTAAAAGAGTATTATATAAAACTCCT
CACATATGAAAGCTTGTTTTCAGACCCTTTAGTTATAGATGAGGTAATATATGTGTCTAAGAAGAAGTATGGGGTTAGGT
ATTGTGATACCATAGAATTCTTAGATGAAATAGTGCTCAAGTACTTAACGGTTTTACCAATCACGATAAAGGAATATGAG
AGGGCTAAAGAGATTATGAGAAAATACTCAGTTAGACCATCTGACGCCTTTCATATTGCCGTAATGTTAAACAATTCAAT
AAACGTGATCTTAAGTGAAGATAAGGAGTTAGATAAAGTTGTAGAAATAAAGAGAATATGGATTAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9859.53 Da        Isoelectric Point: 5.2739

>AT40168 WP_187146859.1 NZ_AP025226:c1395091-1394831 [Saccharolobus caldissimus]
MTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENISL
EEEFED

Download         Length: 261 bp

>AT40168 NZ_AP025226:c1395091-1394831 [Saccharolobus caldissimus]
TTGACTCTAAGAGTGGAAGTGGGAAAGAAGGGTTATATAATAATTCCTAAAAGTGTAAGGGATTTGGTGGGAATAAAAGA
GGGGGATATCTTAATTTTGACAGTCGTTGGGGATAAGATAATCTTAGAACCTGAGAGGAAGGTTAACATACGAGAAGTTG
TCAAAAAATTAGAAGAACACGAGAGGAAGATATCTTATGCTAAAAGGGCAAGCCTTGGGGAACTTGAGAACATAAGTCTT
GAAGAGGAATTTGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References