Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5380901..5382591 Replicon chromosome
Accession NZ_AP025193
Organism Comamonas thiooxydans strain NR4028

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag Cthiooxydans_RS24830 Protein ID WP_087863883.1
Coordinates 5381713..5382591 (-) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y8THJ5
Locus tag Cthiooxydans_RS24825 Protein ID WP_004340321.1
Coordinates 5380901..5381707 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Cthiooxydans_RS24800 (Cthiooxydans_48240) 5375907..5376782 - 876 WP_087863886.1 IclR family transcriptional regulator -
Cthiooxydans_RS24805 (Cthiooxydans_48250) 5376910..5377686 - 777 WP_039050300.1 SDR family oxidoreductase -
Cthiooxydans_RS24810 (Cthiooxydans_48260) 5378001..5378759 - 759 WP_087863885.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
Cthiooxydans_RS24815 (Cthiooxydans_48270) 5378879..5379865 - 987 WP_087863884.1 tripartite tricarboxylate transporter substrate binding protein -
Cthiooxydans_RS24820 (Cthiooxydans_48280) 5380058..5380858 - 801 WP_039050301.1 aspartate dehydrogenase -
Cthiooxydans_RS24825 (Cthiooxydans_48290) 5380901..5381707 - 807 WP_004340321.1 IclR family transcriptional regulator Antitoxin
Cthiooxydans_RS24830 (Cthiooxydans_48300) 5381713..5382591 - 879 WP_087863883.1 alpha/beta hydrolase Toxin
Cthiooxydans_RS24835 (Cthiooxydans_48310) 5382600..5383133 - 534 WP_003072476.1 cupin domain-containing protein -
Cthiooxydans_RS24840 (Cthiooxydans_48320) 5383393..5385069 - 1677 WP_229227777.1 long-chain-fatty-acid--CoA ligase -
Cthiooxydans_RS24845 (Cthiooxydans_48330) 5385283..5386347 - 1065 WP_004340312.1 fructose-bisphosphate aldolase class II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(44-277)

Antitoxin

Transcription regulator IclR, C-terminal

(137-257)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30671.17 Da        Isoelectric Point: 6.6011

>T40064 WP_087863883.1 NZ_AP025193:c5382591-5381713 [Comamonas thiooxydans]
MHEDLLSLKQQLLQTGFPERLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLGDKARVLAWDAPGYGV
STPLAQSAPADADYAQVLAQSLLVLGVRRCLLVGHSLGALMAARLAVTAAPGLVEQLVLISPAGGYGAPAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS

Download         Length: 879 bp

>T40064 NZ_AP025193:c5382591-5381713 [Comamonas thiooxydans]
ATGCACGAGGATTTGCTGTCGCTGAAACAGCAGCTGCTGCAGACCGGTTTTCCCGAGCGGCTGGTGAAGCTTCCGCAGAA
GGCCCAGGTCGCCTGGCGCGAGGCTGGCGACGCCAGCTCCGATTTTGCGGTGGTGCTGCTGCATGGCATCAGCTCCGGGG
CTGCATCCTGGCTGGATGTGGCGCTGCAGCTGGGTGACAAGGCGCGCGTCCTGGCCTGGGATGCACCCGGCTATGGCGTG
TCGACGCCGCTGGCCCAATCGGCGCCTGCCGATGCCGACTATGCGCAGGTGCTGGCCCAGTCACTGCTGGTGCTCGGTGT
GCGGCGCTGCCTGCTGGTCGGCCATTCCCTGGGCGCCCTGATGGCGGCCAGGCTGGCAGTCACGGCGGCCCCCGGGCTGG
TCGAGCAACTGGTGCTCATCAGCCCGGCGGGCGGCTACGGCGCCCCAGCCAAGGCCGAGCAGCAGGCCAAGGTACGCGAG
GGCCGCCTGGCGGCTCTGGCCGAGAAGGGCGTCGCCGGTCTGGCGGCCGTCATCGATCAGCGCCTGGTGTCCTCCGAGGC
TCCTGAAGCCGTGCGTGCATGGGTGCGCTGGAATACGGCGCGCATGCAGCCGCAGGGCTATGCGCAGGCGGTCGAGCTGC
TTTGCGGCAGCGATCTGGCACAGGCACGGGGCAGGCTTGGCATGCCGGTCGAGGTTTGGGTCGGCGAGCACGATGTGGTG
ACTACACCTGCAGCTTGCAAGTCCTGGTCCGAACTGCTGGGCGCGCACTACGGTACGCTTGCGGCTGCCGGTCATGCTTC
ACCCGTGGAACAACCAATGGAGGTCGCGCATAGGCTGGCATCTTTGTTGAACCAAAGCTATTGCCCCAATACCAGCTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29259.22 Da        Isoelectric Point: 5.3811

>AT40064 WP_004340321.1 NZ_AP025193:c5381707-5380901 [Comamonas thiooxydans]
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNIDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR

Download         Length: 807 bp

>AT40064 NZ_AP025193:c5381707-5380901 [Comamonas thiooxydans]
ATGAGCGAAACTTCCGAGATTTCAACCAACGAACAAGACCGTTACACCGTGCCCGCTCTGGACCGAGGACTGCGCCTGCT
GGCCTGCTTTGGCCCGGCGCAACCGGTCTGGAGCGCACCCGAGCTGGCGCGCAGCCTCGAGCTGCCGCGCTCCACGGTGT
TTCGCATGTTGACCACGCTTGAAAACTCGGGGTATCTGCAGCGCAGCGGCACCGAATACCGGCTCGGTCTGGCCGTGCTG
CGCCTGGGCTATGACTACCTGTCCACCCAGCCGCTGGCGCAACTGGCCGAGCCTGTGCTGCAGGCCTTGTGCGATGAGCT
GGGCATGACCAGCAATCTTGCATTGCGCGACGGCACTTCCGTGGTCTATGTGGCACGCGTCACTCCGTCCGGAGCATTCC
AGGGCGCTGTGCGCGTGGGTTCGCGTCTGCCGGCGCATGCGACGGTGCTGGGACGAGCCCTGTTGCATGACATGGACGGC
GCGCAGCTGCGCTCGGTGTTTGGTGGCGAGGAACTGCCCCAGTTCTCCGAGAGCACGCCGCGCAATATCGACGAGCTGCT
GCGCCTGCTGGCCGAGGATCGCGAGCGTGGCTATGCCATGGGCGAGGGCTTTTACGAGCCTGGCGTTTCGAGTATTGCAG
CGCCGGTGCGCGCCGCAGACGGGCGGGTGGTTGCGGGGCTGGCCATGGCCATTCCGTTTACCGAGCTGGGGCCCGAAAAA
ACCCAGCTCTGGGTGCAGAAGGTGCAGCAGGCGGCAGAGACTCTGTCCGCTCATTTGCGCCAGCAGCACCCGGACCATTT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y8THJ5

References