Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2676819..2678355 Replicon chromosome
Accession NZ_AP025193
Organism Comamonas thiooxydans strain NR4028

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag Cthiooxydans_RS12285 Protein ID WP_087864252.1
Coordinates 2677057..2678355 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag Cthiooxydans_RS12280 Protein ID WP_087864253.1
Coordinates 2676819..2677067 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Cthiooxydans_RS12265 (Cthiooxydans_23630) 2673525..2674400 + 876 WP_039051041.1 hypothetical protein -
Cthiooxydans_RS12270 (Cthiooxydans_23640) 2674492..2676324 + 1833 WP_087864255.1 dihydrolipoyl dehydrogenase -
Cthiooxydans_RS12275 (Cthiooxydans_23650) 2676489..2676641 + 153 WP_087864254.1 aldehyde-activating protein -
Cthiooxydans_RS12280 (Cthiooxydans_23660) 2676819..2677067 + 249 WP_087864253.1 helix-turn-helix transcriptional regulator Antitoxin
Cthiooxydans_RS12285 (Cthiooxydans_23670) 2677057..2678355 + 1299 WP_087864252.1 type II toxin-antitoxin system HipA family toxin Toxin
Cthiooxydans_RS12290 (Cthiooxydans_23680) 2678590..2679066 + 477 WP_080692925.1 GFA family protein -
Cthiooxydans_RS12295 (Cthiooxydans_23690) 2679199..2680569 - 1371 WP_087864251.1 MFS transporter -
Cthiooxydans_RS12300 (Cthiooxydans_23700) 2681345..2681701 - 357 WP_041744109.1 zinc ribbon domain-containing protein YjdM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(153-395)

Antitoxin

Transcription regulator, HipB-like

(8-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 47114.20 Da        Isoelectric Point: 7.5324

>T40062 WP_087864252.1 NZ_AP025193:2677057-2678355 [Comamonas thiooxydans]
MEHELEVWLFDGRVGSLSLVHGRLSFAYATDWLALPQATALSQSLPLQAKPFDDHQTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPQTNRAGATGAPGDVEWLSDQKLLALLDELPRRPMLAGDDGLRLSLAGAQD
KLPVVVDESIPGAVRIGLPRNGAPSSHILKPAIHAVEDSVANEGFCMLLAQVMGLRPANARIQSVLGRSFLLVKRYDREL
NAQDLHQPQLQRLHQEDFCQALGVVPELKYQNEGGPGLAQCFALLRSVTRPSAPQVLRLLDGAIFNALIGNHDAHGKNFS
LLYGGRAPVLAPFYDLLTTAIYPQLTPKMAMKIGSKYKFSELEARHWEQFAEEAGLAKAATRKRLQQLANELPAAARKLQ
AAPPHGFAGNAVVTQIVQLIEQRCALTLRRLA

Download         Length: 1299 bp

>T40062 NZ_AP025193:2677057-2678355 [Comamonas thiooxydans]
ATGGAGCATGAACTCGAAGTCTGGCTGTTTGATGGGCGCGTCGGCAGTCTGTCGCTGGTGCATGGGCGGCTGAGCTTTGC
CTATGCGACCGACTGGTTGGCGCTGCCGCAGGCCACGGCTTTATCGCAGTCGCTGCCGCTGCAGGCTAAACCTTTTGACG
ATCATCAGACCCGGCCGTTCTTCGCCGGTCTGCTGCCCGAGGGGCAGATGCGGCGCCTGATTGCCCAGCAGTTTCAGGTG
TCGGGCCAAAACGATTTTGCGCTGCTGGACCATATTGGCGGCGAATGCGCGGGGGCCGTGACCTTTCTGGAGCCGGGGCA
GGCCTTGCCGCAGACTAACAGGGCTGGGGCGACCGGGGCACCGGGTGATGTGGAGTGGCTCAGCGATCAAAAGCTGCTCG
CCTTGCTGGACGAGCTGCCGCGTCGCCCCATGCTGGCGGGAGATGACGGGCTGCGGCTATCGCTGGCAGGGGCGCAGGAC
AAGTTGCCCGTGGTGGTGGACGAGAGCATTCCGGGCGCAGTGCGTATCGGTCTGCCGCGCAACGGCGCTCCCAGCTCGCA
TATCTTGAAGCCCGCCATCCATGCGGTGGAGGACAGTGTGGCCAATGAAGGCTTTTGCATGCTGCTGGCCCAGGTCATGG
GGCTGCGGCCTGCCAATGCCCGAATCCAGAGCGTGCTGGGCCGCTCGTTTTTGCTGGTGAAGCGCTATGACCGGGAGCTG
AATGCTCAAGATCTGCACCAGCCGCAGTTGCAACGTCTGCATCAGGAAGACTTTTGCCAGGCGCTGGGCGTGGTGCCCGA
GCTGAAGTACCAGAACGAGGGCGGGCCAGGCCTGGCGCAATGCTTTGCCCTGCTGCGCAGCGTGACCCGGCCCAGCGCGC
CTCAGGTGCTGCGGCTGCTGGATGGGGCGATCTTCAATGCCTTGATTGGCAACCATGATGCCCATGGCAAGAATTTCTCG
CTGCTTTATGGAGGAAGGGCGCCTGTGCTGGCACCGTTCTACGACCTGCTGACTACAGCGATTTACCCCCAGCTGACGCC
CAAGATGGCAATGAAGATTGGCAGCAAATACAAGTTCAGCGAGCTGGAGGCCAGGCACTGGGAGCAGTTTGCGGAAGAAG
CAGGCCTTGCCAAGGCGGCGACGCGCAAGCGTTTGCAGCAGCTGGCGAACGAACTACCCGCTGCCGCGCGCAAGCTGCAG
GCCGCGCCACCGCATGGTTTTGCGGGCAATGCCGTGGTGACGCAGATCGTGCAGCTGATAGAGCAGCGCTGCGCCTTGAC
GCTGAGGCGCTTGGCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8600.84 Da        Isoelectric Point: 7.2033

>AT40062 WP_087864253.1 NZ_AP025193:2676819-2677067 [Comamonas thiooxydans]
MSTIQTTEQLGAALRTARKQLGLTQPQLALAAGVGTRFIVDLEAGKPTVRLEHVLRVIDALGGELQLDGLPNTASEGTRH
GA

Download         Length: 249 bp

>AT40062 NZ_AP025193:2676819-2677067 [Comamonas thiooxydans]
ATGTCCACCATCCAAACAACCGAGCAACTGGGCGCGGCCTTGCGCACCGCCCGTAAACAACTGGGGCTGACCCAGCCGCA
GCTTGCCTTGGCCGCAGGCGTGGGCACGCGTTTTATTGTGGATCTCGAGGCTGGCAAGCCCACGGTGCGGCTGGAGCATG
TGCTGCGGGTGATCGATGCGCTGGGCGGGGAGTTGCAGTTGGACGGCTTGCCGAATACAGCTTCTGAGGGCACACGCCAT
GGAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References