Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 378503..379029 Replicon chromosome
Accession NZ_AP025180
Organism Escherichia coli strain JP538

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag R5G_RS01910 Protein ID WP_000323025.1
Coordinates 378503..378790 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag R5G_RS01915 Protein ID WP_000534858.1
Coordinates 378790..379029 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R5G_RS01860 (373527) 373527..373742 - 216 WP_000839590.1 phage lysis protein EssD -
R5G_RS01865 (373962) 373962..374132 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
R5G_RS01870 (374496) 374496..374711 - 216 WP_000066484.1 cold shock-like protein CspB -
R5G_RS01875 (375012) 375012..375224 + 213 WP_000087756.1 cold shock-like protein CspF -
R5G_RS01880 (375279) 375279..375368 + 90 WP_120795389.1 hypothetical protein -
R5G_RS01885 (375646) 375646..376398 - 753 WP_001047135.1 antitermination protein -
R5G_RS01890 (376412) 376412..377461 - 1050 WP_001265198.1 DUF968 domain-containing protein -
R5G_RS01895 (377463) 377463..377741 - 279 WP_012304870.1 hypothetical protein -
R5G_RS01900 (377808) 377808..378059 - 252 WP_000980994.1 protein Rem -
R5G_RS01905 (378276) 378276..378431 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
R5G_RS01910 (378503) 378503..378790 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
R5G_RS01915 (378790) 378790..379029 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
R5G_RS01920 (379054) 379054..379359 + 306 WP_001326990.1 protein YdfV -
R5G_RS01925 (379662) 379662..380312 + 651 WP_000993956.1 IS66-like element accessory protein TnpA -
R5G_RS01930 (380312) 380312..380659 + 348 WP_000624618.1 IS66 family insertion sequence element accessory protein TnpB -
R5G_RS01935 (380679) 380679..382250 + 1572 WP_000381442.1 IS66 family transposase -
R5G_RS01940 (382265) 382265..382606 + 342 WP_096215997.1 FlxA-like family protein -
R5G_RS01945 (383043) 383043..383192 - 150 WP_011443592.1 protein YdfW -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 343023..409720 66697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T40032 WP_000323025.1 NZ_AP025180:c378790-378503 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T40032 NZ_AP025180:c378790-378503 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT40032 WP_000534858.1 NZ_AP025180:c379029-378790 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT40032 NZ_AP025180:c379029-378790 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References