Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 957858..958944 Replicon chromosome
Accession NZ_AP025158
Organism Thermus thermophilus strain TMY

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag TthTMY_RS05190 Protein ID WP_096410522.1
Coordinates 957858..958469 (+) Length 204 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag TthTMY_RS05195 Protein ID WP_096410523.1
Coordinates 958531..958944 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TthTMY_RS05170 (TthTMY_10340) 954053..956053 - 2001 WP_223903505.1 single-stranded-DNA-specific exonuclease RecJ -
TthTMY_RS05175 (TthTMY_10350) 956050..956367 - 318 WP_011228484.1 lipopolysaccharide assembly protein LapA domain-containing protein -
TthTMY_RS05180 (TthTMY_10360) 956355..957062 - 708 WP_096410520.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
TthTMY_RS05185 (TthTMY_10370) 957067..957831 - 765 WP_096410521.1 indole-3-glycerol phosphate synthase TrpC -
TthTMY_RS05190 (TthTMY_10380) 957858..958469 + 612 WP_096410522.1 PIN domain-containing protein Toxin
TthTMY_RS05195 (TthTMY_10390) 958531..958944 + 414 WP_096410523.1 helix-turn-helix domain-containing protein Antitoxin
TthTMY_RS05200 (TthTMY_10400) 958948..959775 + 828 WP_096410524.1 patatin-like phospholipase family protein -
TthTMY_RS05205 (TthTMY_10410) 959750..960145 - 396 WP_093008220.1 hypothetical protein -
TthTMY_RS05210 (TthTMY_10420) 960154..960879 - 726 WP_172844691.1 amino acid ABC transporter ATP-binding protein -
TthTMY_RS05215 (TthTMY_10430) 960894..962867 - 1974 WP_223903506.1 TRAP transporter permease -
TthTMY_RS05220 (TthTMY_10440) 962924..963868 - 945 WP_096410526.1 TAXI family TRAP transporter solute-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-120)

Antitoxin

Helix-turn-helix domain, group 17

(67-114)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 23646.37 Da        Isoelectric Point: 4.9138

>T39953 WP_096410522.1 NZ_AP025158:957858-958469 [Thermus thermophilus]
MARPLPRTLFLDACVLYPAPIRDLFVGLALEGLVRLKWNRRVQEEWIHNLLKDRPDLTPEQQARIWATPEKMKEVLAFQE
PLVEGYESLVEEIQLPDEDDRHVVAAAWWGKAEAILTFNLRDFPEEELGRWELLALHPDDYLTELAERLIRKNFLLDPLL
GVLRRQRRALRNPPLGVEAFLESLRRAGLITFAEALEAYKGYL

Download         Length: 612 bp

>T39953 NZ_AP025158:957858-958469 [Thermus thermophilus]
ATGGCCCGCCCGCTTCCCAGGACCCTTTTCCTGGATGCTTGCGTCCTTTATCCCGCCCCGATCCGGGACCTCTTCGTGGG
CCTGGCCTTGGAGGGACTTGTGCGGCTCAAGTGGAACCGGCGCGTCCAGGAGGAGTGGATCCACAACCTGCTTAAAGACC
GCCCTGACCTCACCCCGGAGCAGCAGGCGCGGATCTGGGCCACCCCTGAAAAGATGAAGGAAGTTTTGGCGTTCCAAGAA
CCCCTGGTAGAGGGCTACGAGAGTCTGGTGGAGGAAATCCAGCTCCCCGATGAAGACGACCGCCACGTGGTGGCCGCCGC
CTGGTGGGGAAAAGCGGAGGCCATCCTCACCTTCAACCTCAGGGACTTTCCCGAAGAGGAGCTTGGCCGCTGGGAACTCC
TGGCCCTCCACCCCGACGACTACCTCACAGAACTTGCCGAAAGGCTGATCCGGAAAAACTTCCTGCTTGACCCTCTTCTT
GGTGTGCTTCGGCGCCAGCGCCGCGCCCTGCGCAACCCCCCTCTCGGGGTGGAGGCCTTCCTGGAAAGCCTGAGGCGGGC
CGGGCTGATCACCTTCGCAGAAGCCCTTGAGGCCTACAAGGGGTACCTCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15155.71 Da        Isoelectric Point: 9.5324

>AT39953 WP_096410523.1 NZ_AP025158:958531-958944 [Thermus thermophilus]
MGGLLFTSRPSAEAVKAFREKLAPGKVLHLEETSLVLTPELARLFRELLGALLRGEAVRIVPLEAELTTGQAAELLGVSR
PYLVRLLEEGKIPHHKVGTHRRVRAKDLLAYLEASRKRGRELLDELIGEAQELGLGY

Download         Length: 414 bp

>AT39953 NZ_AP025158:958531-958944 [Thermus thermophilus]
ATGGGCGGTCTCCTCTTCACCTCTAGGCCCTCGGCGGAAGCGGTCAAGGCCTTCCGGGAAAAGCTCGCCCCCGGGAAGGT
TCTGCACCTCGAGGAAACCTCTTTGGTGCTCACCCCGGAGCTGGCCCGGCTTTTCCGGGAGCTTTTGGGGGCGCTTTTGC
GGGGTGAGGCGGTGCGCATCGTTCCCCTGGAAGCGGAGCTCACCACGGGCCAGGCGGCCGAGCTCCTCGGGGTCTCCCGG
CCTTACCTGGTCCGGCTTTTGGAGGAAGGCAAGATTCCCCACCACAAGGTGGGGACCCACCGCCGGGTCCGGGCCAAGGA
CCTCCTGGCCTACCTGGAGGCTTCCCGGAAGCGGGGCAGGGAGCTTTTGGACGAGCTTATCGGCGAGGCCCAGGAGCTCG
GCCTGGGGTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References