Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1706208..1706892 Replicon chromosome
Accession NZ_AP024957
Organism Paraburkholderia terrae strain KU-64

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PTKU64_RS37835 Protein ID WP_091783245.1
Coordinates 1706707..1706892 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PTKU64_RS37830 Protein ID WP_229515762.1
Coordinates 1706208..1706627 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTKU64_RS37810 (PTKU64_75040) 1701667..1702998 + 1332 WP_229515760.1 FAD-binding oxidoreductase -
PTKU64_RS37815 (PTKU64_75050) 1702995..1703906 + 912 WP_007583258.1 ABC transporter permease -
PTKU64_RS37820 (PTKU64_75060) 1703903..1704700 + 798 WP_042306077.1 ABC transporter permease -
PTKU64_RS37825 (PTKU64_75070) 1704721..1706148 + 1428 WP_229515761.1 aldehyde dehydrogenase family protein -
PTKU64_RS37830 (PTKU64_75080) 1706208..1706627 - 420 WP_229515762.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PTKU64_RS37835 (PTKU64_75090) 1706707..1706892 - 186 WP_091783245.1 type II toxin-antitoxin system HicA family toxin Toxin
PTKU64_RS37840 (PTKU64_75100) 1707014..1708699 - 1686 WP_229515763.1 GMC family oxidoreductase N-terminal domain-containing protein -
PTKU64_RS37845 (PTKU64_75110) 1708813..1709823 - 1011 WP_229516939.1 ABC transporter substrate-binding protein -
PTKU64_RS37850 (PTKU64_75120) 1710074..1710418 - 345 WP_091783251.1 cupin domain-containing protein -
PTKU64_RS37855 (PTKU64_75130) 1710459..1711436 - 978 WP_229515764.1 M14 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-66)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7063.14 Da        Isoelectric Point: 11.1658

>T39852 WP_091783245.1 NZ_AP024957:c1706892-1706707 [Paraburkholderia terrae]
MKYSEFRKWLKQQGATFEKHRSGSSHYRVTLNGRTTIFPDHGAKEMGKGLVEAIRKQLGIR

Download         Length: 186 bp

>T39852 NZ_AP024957:c1706892-1706707 [Paraburkholderia terrae]
ATGAAATACAGCGAGTTCAGGAAGTGGCTGAAACAGCAAGGTGCGACGTTCGAAAAGCACCGAAGCGGCTCAAGTCACTA
CCGGGTGACGCTCAATGGCAGGACCACCATCTTCCCCGATCACGGTGCGAAGGAAATGGGTAAAGGACTGGTGGAAGCCA
TCAGGAAGCAGCTCGGTATCAGGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15238.57 Da        Isoelectric Point: 4.9562

>AT39852 WP_229515762.1 NZ_AP024957:c1706627-1706208 [Paraburkholderia terrae]
MLSYPISLTPDDNGTLLVTFPDVPEAITVGDDEDDAKAQALDALEAAFEIYFAEKRSIPMPSKAKRGQSVVTLPALVTAK
VLLADEMLRQNVRKAELARRLSVNQVQVDRLLNFGHSSKIEMVESAFAVLGKRLDVRAV

Download         Length: 420 bp

>AT39852 NZ_AP024957:c1706627-1706208 [Paraburkholderia terrae]
ATGCTCAGCTACCCGATCAGCCTGACACCCGACGACAACGGAACGCTGCTCGTCACGTTTCCTGATGTTCCGGAAGCCAT
CACCGTCGGCGACGACGAAGACGACGCGAAAGCGCAAGCGCTGGATGCGCTCGAGGCCGCGTTCGAAATCTACTTCGCGG
AGAAGCGAAGCATCCCGATGCCTTCGAAGGCCAAACGCGGGCAATCCGTCGTTACGTTGCCGGCGCTTGTGACCGCGAAA
GTGTTGCTCGCGGATGAAATGCTCCGCCAGAACGTGCGAAAGGCTGAACTCGCGCGACGGCTCAGCGTCAATCAGGTGCA
GGTCGATCGACTTCTGAACTTCGGCCATTCATCGAAGATCGAGATGGTCGAGTCGGCGTTTGCGGTACTGGGTAAGCGTC
TCGATGTGCGCGCGGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References